Birchmeier Carmen, Bennett David L H
Developmental Biology, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
The Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
Curr Top Dev Biol. 2016;116:45-64. doi: 10.1016/bs.ctdb.2015.11.009. Epub 2016 Feb 1.
Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system (PNS). Myelin is formed in the early postnatal period, and developmental myelination in the PNS depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.
髓磷脂对于中枢和外周神经系统（PNS）中轴突快速且准确地传导电冲动至关重要。髓磷脂在出生后早期形成，PNS中的发育性髓鞘形成依赖于由Nrg1/ErbB受体提供的轴突信号。此外，成年期有效的神经修复和髓鞘再生需要Nrg1。我们在此讨论Nrg1/ErbB在发育性髓鞘形成和神经损伤后髓鞘再生中的功能异同。
