双-[4-甲氧基-3-(6-芳基-7H-[1,2,4]三唑并[3,4-b][1,3,4]-噻二嗪-3-基)苯基]甲烷和双-[(三唑并[3,4-b]噻二嗪并-3-基)苯基]甲烷的合成与抗菌活性

Synthesis and Antimicrobial Activity of Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes.

作者信息

Srinivas Avula

出版信息

Acta Chim Slov. 2016;63(1):173-9. doi: 10.17344/acsi.2015.2124.

DOI:10.17344/acsi.2015.2124

Abstract

A series of novel Bis-[4-methoxy-3-(6-aryl-7H-[1,2,4]tria zolo[3,4-b][1,3,4]-thiadiazin-3-yl)phenyl]methanes and Bis-[(triazolo[3,4-b]thiadiazipin-3-yl)phenyl]methanes ( 5a-e & 6a-e ) has been synthesized and characterized by IR, (1)H NMR, (13)C NMR, MS and elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Klobsinella aerogenes and Chromobacteriumviolaceum and antifungal activity against Candida albicans, Aspergillus fumigatus, Trichophyton rubrum and Trichophyton mentagrophytes. Compounds 5b, 5d,5e, 6b, 6c and 6e exhibited potent activity against the test bacteria and fungi, and emerged as potential molecules for further development.

摘要

一系列新型的双-[4-甲氧基-3-(6-芳基-7H-[1,2,4]三唑并[3,4-b][1,3,4]-噻二嗪-3-基)苯基]甲烷和双-[(三唑并[3,4-b]噻二嗪并-3-基)苯基]甲烷(5a - e和6a - e)已被合成，并通过红外光谱、核磁共振氢谱、核磁共振碳谱、质谱和元素分析进行了表征。对所有新合成的化合物进行了针对枯草芽孢杆菌、金黄色葡萄球菌、产气克雷伯菌和紫色色杆菌的抗菌活性以及针对白色念珠菌、烟曲霉、红色毛癣菌和须癣毛癣菌的抗真菌活性筛选。化合物5b、5d、5e、6b、6c和6e对受试细菌和真菌表现出强效活性，并成为有进一步开发潜力的分子。

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