School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing, 100083, China.
School of Water Resources and Environment, China University of Geosciences (Beijing), Beijing, 100083, China; China National Environmental Monitoring Center, Beijing, 100012, China.
Environ Pollut. 2016 Jun;213:482-488. doi: 10.1016/j.envpol.2016.03.005. Epub 2016 Mar 10.
Diethylhexyl phthalate (DEHP) is considered to be an endocrine disruptor, which unlike other chemicals that have either non-specific (e.g., narcotics) or more generalized reactive modes of action, affect the Hypothalamic-pituitary-gonadal (HPG) axis and tend to have specific interactions with particular molecular targets within biochemical pathways. Responding to this challenge, a novel method for deriving predicted no-effect concentration (PNEC) and probabilistic ecological risk assessment (PERAs) for DEHP based on long-term exposure to potentially sensitive species with appropriate apical endpoints was development for protection of Chinese surface waters. PNECs based on potencies to cause lesions in reproductive tissues of fishes, which ranged from 0.04 to 0.20 μg DEHP L(-1), were significantly less than those derived based on other endpoints or other taxa, such as invertebrates. An assessment of risks posed by DEHP to aquatic organisms in surface waters of China showed that 88.17% and 78.85% of surface waters in China were predicted to pose risks to reproductive fitness of fishes with thresholds of protection for aquatic organisms based on 5% (HC5) and 10% (HC10), respectively. Assessment of risks of effects based on effects mediated by the HPG-axis should consider effects on chronic, non-lethal endpoints for specific taxa, especially for reproductive fitness of fishes.
邻苯二甲酸二（2-乙基己基）酯（DEHP）被认为是一种内分泌干扰物，与其他具有非特异性（如麻醉剂）或更广泛的一般性反应模式的化学物质不同，它会影响下丘脑-垂体-性腺（HPG）轴，并倾向于与生化途径中的特定分子靶标发生特异性相互作用。为应对这一挑战，开发了一种新方法，用于基于潜在敏感物种的长期暴露，通过适当的顶端终点，推导出 DEHP 的预测无效应浓度（PNEC）和概率生态风险评估（PERAs），以保护中国地表水。基于鱼类生殖组织损伤的效力推导出的 PNEC 值范围为 0.04 至 0.20μg DEHP/L，显著低于基于其他终点或其他分类群（如无脊椎动物）推导的值。对中国地表水受 DEHP 影响的水生生物的风险评估表明，中国 88.17%和 78.85%的地表水预计会对鱼类的生殖适应能力造成风险，其保护水生生物的阈值分别基于 5%（HC5）和 10%（HC10）。基于 HPG 轴介导的效应进行的效应风险评估应考虑特定分类群的慢性、非致死性终点的效应，尤其是鱼类的生殖适应能力。
