Öztürk İlker, Aslan Kezban, Bozdemir Hacer, Foldvary-Schaefer Nancy
Çukurova University, Faculty of Medicine, Department of Neurology, 1380 Sarıçam, Adana, Turkey.
Cleveland Clinic Epilepsy and Sleep Disorders Centers, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Epilepsy Behav. 2016 Apr;57(Pt A):192-195. doi: 10.1016/j.yebeh.2016.02.013. Epub 2016 Mar 10.
Restless Legs Syndrome (RLS) is a common disorder characterized by an irresistible urge to move the legs particularly during rest in the evenings often leading to insomnia and daytime impairment. No prior studies estimate the prevalence of RLS in a diverse sample of adults with epilepsy using standard diagnostic criteria.
A total of 225 patients with epilepsy (61.8% female; mean age 33.3 ± 12.3 years) seen in the epilepsy clinic of Çukurova University Neurology Department were included. Restless Legs Syndrome diagnosis was based on structured interviews using internationally accepted criteria. Demographic and epilepsy-related variables were obtained through medical record review.
The prevalence of RLS was 5.8% (n=13). Mean score on the International RLS Study Group rating scale for these subjects was 9.3 ± 3.6 (6-18). Ten (76.9%) patients with RLS scored in the mild range and the remainder in the moderate range of severity. Patients with RLS were not significantly different from others in terms of demographics, epilepsy classification or duration, treatment regimen (polytherapy vs. monotherapy), patient-reported sleep assessment, or relevant laboratory data.
The prevalence of RLS in adults with epilepsy was similar to that observed in the adult general Turkish population (3.18-5.2%), although we excluded subjects with conditions associated with RLS, rendering ours a conservative estimate. While preliminary, these findings support the need for future studies exploring RLS in epilepsy given the potential impact of untreated sleep disorders and sleep deprivation on seizures and quality of life in people with epilepsy.
不宁腿综合征（RLS）是一种常见疾病，其特征是腿部有不可抗拒的运动冲动，尤其是在晚上休息时，常导致失眠和日间功能障碍。此前尚无研究使用标准诊断标准估计不同类型成年癫痫患者中RLS的患病率。
纳入了在库库洛瓦大学神经科癫痫门诊就诊的225例癫痫患者（女性占61.8%；平均年龄33.3±12.3岁）。不宁腿综合征的诊断基于采用国际公认标准的结构化访谈。通过查阅病历获取人口统计学和癫痫相关变量。
RLS的患病率为5.8%（n = 13）。这些受试者在国际RLS研究组评分量表上的平均得分为9.3±3.6（6 - 18）。10例（76.9%）RLS患者的严重程度评分为轻度，其余为中度。RLS患者在人口统计学、癫痫分类或病程、治疗方案（联合治疗与单一治疗）、患者报告的睡眠评估或相关实验室数据方面与其他患者无显著差异。
癫痫成年患者中RLS的患病率与土耳其成年普通人群中观察到的患病率相似（3.18 - 5.2%），尽管我们排除了与RLS相关疾病的受试者，因此我们的估计较为保守。虽然这些发现是初步的，但鉴于未治疗的睡眠障碍和睡眠剥夺对癫痫患者的癫痫发作及生活质量可能产生影响，这些发现支持未来开展探索癫痫患者中RLS的研究。
