镓-多柔比星用于肿瘤性骨软化症的肿瘤定位
Ga-DOTATATE for Tumor Localization in Tumor-Induced Osteomalacia.
作者信息
El-Maouche Diala, Sadowski Samira M, Papadakis Georgios Z, Guthrie Lori, Cottle-Delisle Candice, Merkel Roxanne, Millo Corina, Chen Clara C, Kebebew Electron, Collins Michael T
机构信息
Division of Endocrinology (D.E.-M.), Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida; Skeletal Clinical Studies Unit (D.E.-M., L.G., M.T.C.), Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland; Thoracic and Endocrine Surgery (S.M.S.), University Hospitals of Geneva, Geneva, Switzerland; The Endocrine Oncology Branch (S.M.S., C.C.-D., R.M., E.K.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Positron Emission Tomography Department (G.Z.P., C.M.), Warren Grant Magnusson Clinical Center, National Institutes of Health, Bethesda, Maryland; Nuclear Medicine Division (C.C.C.), Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland.
出版信息
J Clin Endocrinol Metab. 2016 Oct;101(10):3575-3581. doi: 10.1210/jc.2016-2052. Epub 2016 Aug 17.
CONTEXT
Phosphaturic mesenchymal tumors (PMTs) are small, typically difficult to localize, and express somatostatin receptors. Recent work suggests imaging studies using Gallium (Ga)-conjugated somatostatin peptide analogues, such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)TATE, which enables somatostatin receptor imaging with positron emission tomography (PET), may be useful at identifying these tumors.
OBJECTIVE
Our objective was to evaluate the use of Ga-DOTATATE PET/computed tomography (CT) for tumor localization in tumor-induced osteomalacia (TIO).
DESIGN
This was a single-center prospective study of patients with TIO.
SETTING
The study was conducted at the National Institutes of Health Clinical Center between February 2014 and February 2015.
SUBJECTS
Eleven subjects (six females, five males) with TIO were included.
INTERVENTION
Subjects underwent Ga-DOTATATE PET/CT in addition to In-pentetreotide single-photon emission CT (Octreoscan- SPECT/CT) and fluorodeoxyglucose-PET/CT (F FDG-PET/CT) scan.
MAIN OUTCOME MEASURES
Localization of PMTs on the previously described imaging modalities were determined.
RESULTS
The tumor was successfully localized in 6/11 (54.5%) subjects (one was metastatic). The tumor was identified by Ga-DOTATATE in all six cases. Both Octreoscan-SPECT/CT and F FDG-PET each identified the tumor in 4/6. In no cases was Ga-DOTATATE the only imaging study to identify the tumor.
CONCLUSIONS
In this first prospective study comparing Ga-DOTATATE PET/CT to Octreoscan-SPECT/CT and F FDG-PET in TIO localization, Ga-DOTATATE PET/CT demonstrated the greatest sensitivity and specificity, suggesting that it may be the best single study for localization of PMTs in TIO.
背景
磷酸尿性间叶肿瘤（PMTs）体积小，通常难以定位，且表达生长抑素受体。最近的研究表明，使用镓（Ga）缀合的生长抑素肽类似物进行成像研究，如1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸（DOTA）TATE，可通过正电子发射断层扫描（PET）实现生长抑素受体成像，这可能有助于识别这些肿瘤。
目的
我们的目的是评估Ga-DOTATATE PET/计算机断层扫描（CT）在肿瘤诱导的骨软化症（TIO）中用于肿瘤定位的情况。
设计
这是一项针对TIO患者的单中心前瞻性研究。
地点
该研究于2014年2月至2015年2月在国立卫生研究院临床中心进行。
研究对象
纳入了11名TIO患者（6名女性，5名男性）。
干预措施
除了进行铟-喷替肽单光子发射CT（奥曲肽扫描-SPECT/CT）和氟脱氧葡萄糖-PET/CT（18F FDG-PET/CT）扫描外，研究对象还接受了Ga-DOTATATE PET/CT检查。
主要观察指标
确定PMTs在上述成像方式上的定位情况。
结果
肿瘤在6/11（54.5%）的研究对象中成功定位（1例为转移性肿瘤）。在所有6例中，肿瘤均通过Ga-DOTATATE得以识别。奥曲肽扫描-SPECT/CT和18F FDG-PET分别在4/6的病例中识别出肿瘤。在任何病例中，Ga-DOTATATE都不是唯一识别出肿瘤的成像检查。
结论
在这项首次将Ga-DOTATATE PET/CT与奥曲肽扫描-SPECT/CT和18F FDG-PET用于TIO定位进行比较的前瞻性研究中，Ga-DOTATATE PET/CT显示出最高的敏感性和特异性，表明它可能是TIO中PMTs定位的最佳单一检查方法。
Zotero 插件