Covacu Ruxandra, Philip Hagit, Jaronen Merja, Almeida Jorge, Kenison Jessica E, Darko Samuel, Chao Chun-Cheih, Yaari Gur, Louzoun Yoram, Carmel Liran, Douek Daniel C, Efroni Sol, Quintana Francisco J
Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel.
Cell Rep. 2016 Mar 22;14(11):2733-44. doi: 10.1016/j.celrep.2016.02.056. Epub 2016 Mar 10.
The T cell receptor (TCR) controls the cellular adaptive immune response to antigens, but our understanding of TCR repertoire diversity and response to challenge is still incomplete. For example, TCR clones shared by different individuals with minimal alteration to germline gene sequences (public clones) are detectable in all vertebrates, but their significance is unknown. Although small in size, the zebrafish TCR repertoire is controlled by processes similar to those operating in mammals. Thus, we studied the zebrafish TCR repertoire and its response to stimulation with self and foreign antigens. We found that cross-reactive public TCRs dominate the T cell response, endowing a limited TCR repertoire with the ability to cope with diverse antigenic challenges. These features of vertebrate public TCRs might provide a mechanism for the rapid generation of protective T cell immunity, allowing a short temporal window for the development of more specific private T cell responses.
T细胞受体（TCR）控制细胞对抗原的适应性免疫反应，但我们对TCR库多样性及对挑战的反应的理解仍不完整。例如，在所有脊椎动物中都能检测到不同个体共享的、种系基因序列变化极小的TCR克隆（公共克隆），但其意义尚不清楚。斑马鱼的TCR库虽然规模较小，但其受与哺乳动物中运作的过程相似的机制控制。因此，我们研究了斑马鱼的TCR库及其对自身和外来抗原刺激的反应。我们发现，交叉反应性公共TCR主导T细胞反应，使有限的TCR库有能力应对各种抗原挑战。脊椎动物公共TCR的这些特征可能为快速产生保护性T细胞免疫提供一种机制，为更具特异性的私有T细胞反应的发展留出一个短暂的时间窗口。
