Rawlings C E, el-Naggar A O, Nashold B S
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710.
Br J Neurosurg. 1989;3(6):633-42. doi: 10.3109/02688698908992686.
The DREZ operation was first done in 1975 on a patient with arm pain following a brachial plexus avulsion. Since then approximately 500 patients have undergone the DREZ procedure under our care for treatment of various pain syndromes including deafferentation pain, post-herpetic neuralgia, and post-paraplegia pain. We report several modifications in instrumentation and technique. Currently, we use two types of electrodes for lesion production. The first is the standard 0.25 mm diameter, thermocouple, temperature monitoring electrode which has a 2 mm long tip for introduction into the spinal cord. A second type, recently modified from the original, is used only for lesioning the nucleus caudalis in patients with trigeminal post-herpetic neuralgia. Its tip is 3 mm long with insulation along the first 1 mm. This allows lesioning of the caudalis nucleus while sparing the more superficial spinocerebellar tracts. We no longer lesion only the dorsal root entry zones at each root level but include all the contiguous substantia gelatinosa between roots. With lesions only 1 mm apart this greatly increases the number of lesions and decreases the incidence of incomplete postoperative pain relief. In patients undergoing caudalis lesioning, we make two rows of lesions, one above the other, from C2 to slightly above the obex. This prevents sparing of the facial midline with resultant residual pain. Finally, lesions are made by heating the electrode tip to 75 degrees C for exactly 15 sec, thus allowing for a more uniform lesion. With these modifications, we have a decreased incidence of incomplete pain relief as well as a decreased incidence of complications, especially in patients undergoing caudalis lesioning.
1975年,首次对一名臂丛神经撕脱后出现手臂疼痛的患者实施了脊髓背根入髓区(DREZ)手术。从那时起,在我们的治疗下,约有500名患者接受了DREZ手术,用于治疗各种疼痛综合征,包括去传入性疼痛、带状疱疹后神经痛和截瘫后疼痛。我们报告了手术器械和技术方面的几处改进。目前,我们使用两种类型的电极来制造损伤。第一种是标准的直径0.25毫米的热电偶温度监测电极,其尖端长2毫米,用于插入脊髓。第二种是最近在原始电极基础上改进的,仅用于三叉神经带状疱疹后神经痛患者的尾状核损伤。其尖端长3毫米,前1毫米有绝缘层。这使得在损伤尾状核时能避免损伤较浅的脊髓小脑束。我们不再仅在每个神经根水平损伤背根入区,而是包括神经根之间所有相邻的胶状质。损伤间距仅1毫米,这大大增加了损伤数量,降低了术后疼痛缓解不完全的发生率。在接受尾状核损伤的患者中,我们从C2到闩部上方稍高处制作两排上下排列的损伤。这可防止面部中线部位未受损伤而导致残留疼痛。最后,通过将电极尖端加热到75摄氏度并持续15秒来制造损伤,从而实现更均匀的损伤。通过这些改进,我们降低了疼痛缓解不完全的发生率以及并发症的发生率,尤其是在接受尾状核损伤的患者中。