Lee Eun-Mi, Kim Ah-Young, Lee Eun-Joo, Park Jin-Kyu, Kim Tae-Hwan, Park Se-Il, Jeong Kyu-Shik
Department of Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea.
J Vet Med Sci. 2016 Jul 1;78(6):1085-8. doi: 10.1292/jvms.15-0715. Epub 2016 Mar 13.
A 13-year-old castrated male Yorkshire terrier dog had a soft splenic mass, which measured 11 cm in the greatest diameter. Microscopically, the parenchyma of the spleen was completely replaced by myxoid substances. Numerous spindle and stellate cells were loosely arranged in the myxoid stroma, and variable vessels of variable sizes were observed in a loose matrix with poorly defined margins. Immunohistochemical analysis showed that tumor cells were positive for desmin and alpha-SMA, but negative for S-100. Interestingly, intravascular tumor embolus with positive α-SMA expression was observed. This case is meaningful, because angiomyxoma, a rare tumor of dogs, occurs in the spleen. Even in human cases, splenic angiomyxoma was not reported.
一只13岁去势的雄性约克夏梗犬脾脏有一个柔软肿物，最大直径为11厘米。显微镜下，脾脏实质完全被黏液样物质取代。大量梭形细胞和星状细胞松散排列于黏液样基质中，在边界不清的疏松基质中可见大小不一的血管。免疫组化分析显示肿瘤细胞结蛋白和α -平滑肌肌动蛋白呈阳性，但S - 100呈阴性。有趣的是，观察到血管内肿瘤栓子α -平滑肌肌动蛋白表达阳性。该病例具有意义，因为血管黏液瘤是犬的一种罕见肿瘤，发生于脾脏。即使在人类病例中，脾脏血管黏液瘤也未见报道。
