Hansson J, Ericsson A E, Axelson H, Johansson M E
Lund University.
Eur J Histochem. 2016 Feb 5;60(1):2567. doi: 10.4081/ejh.2016.2567.
The cellular source for tubular regeneration following kidney injury is a matter of dispute, with reports suggesting a stem or progenitor cells as the regeneration source while linage tracing studies in mice seemingly favor the classical theory, where regeneration is performed by randomly surviving cells. We, and others have previously described a scattered cell population localized to the tubules of human kidney, which increases in number following injury. Here we have characterized the species distribution of these proximal tubular progenitor cells (PTPCs) in kidney tissue from chimpanzee, pig, rat and mouse using a set of human PTPC markers. We detected PTPCs in chimpanzee and pig kidneys, but not in mouse tissue. Also, subjecting mice to the unilateral urethral obstruction model, caused clear signs of tubular injury, but failed to induce the PTPC phenotype in renal tubules.
肾损伤后肾小管再生的细胞来源存在争议，有报道表明干细胞或祖细胞是再生来源，而小鼠的谱系追踪研究似乎支持经典理论，即再生由随机存活的细胞完成。我们和其他人之前描述过一种散在的细胞群，定位于人肾的肾小管，损伤后数量增加。在这里，我们使用一组人近端肾小管祖细胞（PTPC）标志物，对黑猩猩、猪、大鼠和小鼠肾组织中这些近端肾小管祖细胞的物种分布进行了表征。我们在黑猩猩和猪的肾脏中检测到了PTPC，但在小鼠组织中未检测到。此外，对小鼠进行单侧尿道梗阻模型，虽造成了明显的肾小管损伤迹象，但未能诱导肾小管中的PTPC表型。
