Lee Young Ho, Kim Jae-Hoon, Song Gwan Gyu
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Eur J Obstet Gynecol Reprod Biol. 2016 May;200:51-7. doi: 10.1016/j.ejogrb.2016.02.032. Epub 2016 Mar 3.
The aim of this study was to investigate whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL).
We conducted a literature search using the PubMed and EMBASE databases and performed meta-analyses on the associations between IL-10 -1082 G/A, -819 C/T, and -592 C/A polymorphisms and RPL, using fixed- or random-effects models.
A total of 15 papers involving 1858 RPL patients and 1949 controls were considered in this study. Meta-analysis of IL-10 -1082 G/A polymorphism revealed no association between RPL and the IL-10 -1082 G allele (OR=0.999, 95% CI=0.815-1.223, p=0.989). However, meta-analysis of IL-10 -819 C/T polymorphism in all study subjects revealed an association between RPL and the IL-10 -819 C allele (OR=0.680, 95% CI=0.498-0.927, p=0.015). Stratification by ethnicity indicated an association between the IL-10 -819 C allele and RPL in the Asian group (OR=0.421, 95% CI=0.226-0.783, p=0.006), but not in the Caucasian and Arab groups (OR=1.053, 95% CI=0.218-5.077, p=0.949, and OR=0.800, 95% CI=0.606-1.081, p=0.152, respectively). Furthermore, a relationship between the IL-10 -592 C allele and RPL was identified in the Asian group (OR=0.763, 95% CI=0.633-0.919, p=0.004), but not in the Caucasian and Arab groups.
The meta-analyses demonstrate that IL-10 -819 C/T and -592 C/A polymorphisms are associated with RPL susceptibility in Asian women, but not in the Caucasian and Arab populations.
本研究旨在调查白细胞介素-10（IL-10）基因多态性是否与复发性流产（RPL）易感性相关。
我们使用PubMed和EMBASE数据库进行文献检索，并采用固定效应或随机效应模型，对IL-10 -1082 G/A、-819 C/T和-592 C/A基因多态性与RPL之间的关联进行荟萃分析。
本研究共纳入15篇论文，涉及1858例RPL患者和1949例对照。对IL-10 -1082 G/A基因多态性的荟萃分析显示，RPL与IL-10 -1082 G等位基因之间无关联（OR=0.999，95%CI=0.815-1.223，p=0.989）。然而，对所有研究对象的IL-10 -819 C/T基因多态性进行荟萃分析发现，RPL与IL-10 -819 C等位基因之间存在关联（OR=0.680，95%CI=0.498-0.927，p=0.015）。按种族分层显示，亚洲人群中IL-10 -819 C等位基因与RPL之间存在关联（OR=0.421，95%CI=0.226-0.783，p=0.006），而在白种人和阿拉伯人群中无关联（OR分别为1.053，95%CI=0.218-5.077，p=0.949；OR=0.800，95%CI=0.606-1.081，p=0.152）。此外，在亚洲人群中发现IL-10 -592 C等位基因与RPL之间存在关联（OR=0.763，95%CI=0.633-0.919，p=0.004），而在白种人和阿拉伯人群中无关联。
荟萃分析表明，IL-10 -819 C/T和-592 C/A基因多态性与亚洲女性的RPL易感性相关，而与白种人和阿拉伯人群无关。
