Department of Gynecology and Obstetrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Gynecology and Obstetrics, Iran University of Medical Sciences, Tehran, Iran.
Fetal Pediatr Pathol. 2020 Aug;39(4):346-359. doi: 10.1080/15513815.2019.1652379. Epub 2019 Aug 22.
The present meta-analysis was performed to investigate the association of promoter region polymorphisms at IL-6 and IL-18 genes with recurrent pregnancy loss (RPL) risk. An electronic search of the PubMed, Embase, ISI Web of Knowledge and CNKI databases was performed to identify eligible studies up to May 30, 2019. A total of 31 case-control studies were finally selected. Significant associations with the risk of RPL were detected for the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms in overall population. Further, subgroup analyses by ethnicity revealed that the IL-6 -174 G > C and -634 G > C polymorphisms were significantly associated with risk of RPL risk in Asians. Our results suggest that the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms may contribute to the susceptibility of RPL. The IL-18 -607 C > A polymorphism does not appear to influence the development of RPL.
本荟萃分析旨在研究白细胞介素 6（IL-6）和白细胞介素 18（IL-18）基因启动子区域多态性与复发性妊娠丢失（RPL）风险的关联。截至 2019 年 5 月 30 日，通过电子检索 PubMed、Embase、ISI Web of Knowledge 和中国知网数据库，以确定符合条件的研究。最终选择了 31 项病例对照研究。在总体人群中，IL-6-174G>C、-634G>C 和 IL-18-137G>C 多态性与 RPL 风险显著相关。进一步的亚组分析表明，IL-6-174G>C 和 -634G>C 多态性与亚洲人群 RPL 风险显著相关。我们的结果表明，IL-6-174G>C、-634G>C 和 IL-18-137G>C 多态性可能与 RPL 的易感性有关。IL-18-607C>A 多态性似乎不会影响 RPL 的发展。
