Maye Jacqueline E, Betensky Rebecca A, Gidicsin Christopher M, Locascio Joseph, Becker J Alex, Pepin Lesley, Carmasin Jeremy, Rentz Dorene M, Marshall Gad A, Blacker Deborah, Sperling Reisa A, Johnson Keith A
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Neurobiol Aging. 2016 Apr;40:61-67. doi: 10.1016/j.neurobiolaging.2015.12.013. Epub 2015 Dec 28.
Family history (FH) of dementia is a major risk factor for Alzheimer's disease, particularly when the FH is maternal and when the age of dementia onset (AO) is younger. This study tested whether brain amyloid-beta deposition, measured in vivo with (11)C-Pittsburgh compound B (PiB), was associated with parental dementia and/or younger parental AO. Detailed FH and positron emission tomography (PiB) data were acquired in 147 nondemented aging individuals (mean age 75 ± 8). No participant had both positive maternal and paternal FH. A series of analyses revealed that those with maternal, but not paternal, FH had greater levels of PiB retention in a global cortical region than those without FH. PiB retention in maternal FH was not significantly greater than paternal FH. Younger maternal dementia AO was related to greater PiB retention in offspring, whereas younger paternal dementia AO was not. Overall, results suggest that not only is amyloid-beta burden greater in individuals with maternal FH, but also that the burden is greater in association with younger maternal AO.
痴呆症家族史（FH）是阿尔茨海默病的主要危险因素，尤其是当家族史为母系且痴呆症发病年龄（AO）较小时。本研究测试了用（11）C-匹兹堡化合物B（PiB）在体内测量的脑淀粉样蛋白β沉积是否与父母痴呆症和/或父母较小的AO相关。在147名无痴呆的老年人（平均年龄75±8岁）中获取了详细的家族史和正电子发射断层扫描（PiB）数据。没有参与者同时有阳性的母系和父系家族史。一系列分析表明，有母系而非父系家族史的人在全脑皮质区域的PiB保留水平高于没有家族史的人。母系家族史中的PiB保留并不显著高于父系家族史。母亲痴呆症发病年龄较小与后代中更高的PiB保留有关，而父亲痴呆症发病年龄较小则不然。总体而言，结果表明，不仅有母系家族史的个体中淀粉样蛋白β负担更大，而且与母亲较小的发病年龄相关时负担也更大。
