El Tayebi Hend Mohamed, Abdelaziz Ahmed Ihab
Hend Mohamed El Tayebi, Ahmed Ihab Abdelaziz, The Molecular Pathology Research Group, Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt.
World J Gastroenterol. 2016 Mar 7;22(9):2668-77. doi: 10.3748/wjg.v22.i9.2668.
The insulin-like growth factor (IGF) signaling pathway is an important pathway in the process of hepatocarcinogenesis, and the IGF network is clearly dysregulated in many cancers and developmental abnormalities. In hepatocellular carcinoma (HCC), only a minority of patients are eligible for curative treatments, such as tumor resection or liver transplant. Unfortunately, there is a high recurrence of HCC after surgical tumor removal. Recent research efforts have focused on targeting IGF axis members in an attempt to find therapeutic options for many health problems. In this review, we shed lights on the regulation of members of the IGF axis, mainly by microRNAs in HCC. MicroRNAs in HCC attempt to halt the aberrant expression of the IGF network, and a single microRNA can have multiple downstream targets in one or more signaling pathways. Targeting microRNAs is a relatively new approach for identifying an efficient radical cure for HCC.
胰岛素样生长因子（IGF）信号通路是肝癌发生过程中的一条重要通路，IGF网络在许多癌症和发育异常中明显失调。在肝细胞癌（HCC）中，只有少数患者适合接受根治性治疗，如肿瘤切除或肝移植。不幸的是，手术切除肿瘤后HCC的复发率很高。最近的研究工作集中在靶向IGF轴成员，试图为许多健康问题找到治疗选择。在这篇综述中，我们主要阐述了HCC中微小RNA对IGF轴成员的调控。HCC中的微小RNA试图阻止IGF网络的异常表达，单个微小RNA可以在一个或多个信号通路中有多个下游靶点。靶向微小RNA是一种相对较新的方法，用于寻找治疗HCC的有效根治方法。
