YAP1在肝癌干细胞中的作用：已证实的和潜在的机制
The role of YAP1 in liver cancer stem cells: proven and potential mechanisms.
作者信息
Wu Haofeng, Liu Yachong, Liao Zhibin, Mo Jie, Zhang Qiaofeng, Zhang Bixiang, Zhang Lei
机构信息
Hepatic Surgery Center, Institute of Hepato-Pancreato-Bililary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Department of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Medical University; Shanxi Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Taiyuan, 030032, China.
出版信息
Biomark Res. 2022 Jun 7;10(1):42. doi: 10.1186/s40364-022-00387-z.
YAP1 (Yes-associated protein 1) is one of the principal factors that mediates oncogenesis by acting as a driver of gene expression. It has been confirmed to play an important role in organ volume control, stem cell function, tissue regeneration, tumorigenesis and tumor metastasis. Recent research findings show that YAP1 is correlated with the stemness of liver cancer stem cells, and liver cancer stem cells are closely associated with YAP1-induced tumor initiation and progression. This article reviews the advancements made in research on the mechanisms by which YAP1 promotes liver cancer stem cells and discusses some potential mechanisms that require further study.
YAP1（Yes相关蛋白1）是通过作为基因表达的驱动因子介导肿瘤发生的主要因素之一。它已被证实 在器官体积控制、干细胞功能、组织再生、肿瘤发生和肿瘤转移中发挥重要作用。最近的研究结果表明，YAP1与肝癌干细胞的干性相关，且肝癌干细胞与YAP1诱导的肿瘤起始和进展密切相关。本文综述了YAP1促进肝癌干细胞的机制研究进展，并讨论了一些需要进一步研究的潜在机制。
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