Gay Laura, Baker Ann-Marie, Graham Trevor A
Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
F1000Res. 2016 Feb 29;5. doi: 10.12688/f1000research.7210.1. eCollection 2016.
The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.
构成癌症的细胞群体在基因、表观遗传和表型水平上明显具有异质性。在这篇小型综述中，我们总结了人类恶性肿瘤中肿瘤内异质性（ITH）的程度，回顾了导致和维持ITH的机制，并讨论了ITH在癌症预后和治疗方面带来的影响和机遇。
