甲基强的松龙对人淋巴母细胞系核苷代谢的影响。
Effect of methylprednisolone on the nucleoside metabolism of a human lymphoblastoid cell line.
作者信息
Waddell A W, Bird C C, Currie A R
出版信息
Br J Cancer. 1977 Aug;36(2):187-91. doi: 10.1038/bjc.1977.176.
Abstract
Concentrations of methylprednisolone which have lethal effects on human lymphoblastoid cell lines in vitro cause a reduction both in the uptake of uridine and thymidine into acid-soluble material and their incorporation into acid-insoluble material. These effects are virtually instantaneous, which indicates that they do not depend on alterations in gene activity. Normal uptake of nucleosides into cells is by both simple and facilitated diffusion, and methylprednisolone appears to act directly on the cell surface to inhibit only facilitated diffusion uptake.
摘要
在体外对人淋巴母细胞系有致死作用的甲泼尼龙浓度，会使尿苷和胸苷摄取到酸溶性物质中的量减少，以及它们掺入酸不溶性物质中的量减少。这些作用几乎是瞬间发生的，这表明它们不依赖于基因活性的改变。核苷正常进入细胞是通过简单扩散和易化扩散，而甲泼尼龙似乎直接作用于细胞表面，仅抑制易化扩散摄取。
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Effect of hormones on lympatic tissue.激素对淋巴组织的影响。
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Effects of prednisolone on phospholipid metabolism in tissue culture.泼尼松龙对组织培养中磷脂代谢的影响。
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Differentiated functions expressed by cultured mouse lymphoma cells. I. Specificity and kinetics of cell responses to corticosteroids.培养的小鼠淋巴瘤细胞所表达的分化功能。I. 细胞对皮质类固醇反应的特异性和动力学。
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Evidence for induction by cortisol in vitro of a protein inhibitor of transport and phosphorylation processes in rat thymocytes.皮质醇在体外诱导大鼠胸腺细胞中转运和磷酸化过程的一种蛋白质抑制剂的证据。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1269-73. doi: 10.1073/pnas.68.6.1269.
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