精神疾病中的长链非编码RNA
Long noncoding RNAs in psychiatric disorders.
作者信息
Zuo Lingjun, Tan Yunlong, Wang Zhiren, Wang Ke-Sheng, Zhang Xiangyang, Chen Xiangning, Li Chiang-Shan R, Wang Tong, Luo Xingguang
机构信息
Departments of aPsychiatry bCellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut cDepartment of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, Tennessee dDepartment of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, The University of Texas Health Science Center at Houston, Houston, Texas eDepartment of Psychology, Nevada Institute of Personalized Medicine, University of Nevada, Las Vegas, Neveda, USA fBiological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China.
出版信息
Psychiatr Genet. 2016 Jun;26(3):109-16. doi: 10.1097/YPG.0000000000000129.
Long noncoding RNAs (lncRNAs) are nonprotein coding transcripts longer than 200 nucleotides. Many of these lncRNAs have regulatory functions and have recently emerged as major players in governing fundamental biological processes. Here, we review the definition, distribution, identification, databases, analysis, classification, and functions of lncRNAs. We also discuss the potential roles of lncRNAs in the etiological processes of psychiatric disorders and the implications for clinical diagnosis and treatment.
长链非编码RNA（lncRNAs）是长度超过200个核苷酸的非蛋白质编码转录本。其中许多lncRNAs具有调控功能，并且最近已成为调控基本生物学过程的主要参与者。在此，我们综述了lncRNAs的定义、分布、鉴定、数据库、分析、分类及功能。我们还讨论了lncRNAs在精神疾病病因学过程中的潜在作用以及对临床诊断和治疗的意义。
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