Lee Woo Jin, Lee Sang Hyung, Moon Ik Jun, Won Chong Hyun, Chang Sung Eun, Choi Jee Ho, Park Chan-Sik, Suh Cheolwon, Lee Mi Woo
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Acta Derm Venereol. 2016 Nov 2;96(7):888-893. doi: 10.2340/00015555-2404.
Long-term changes in the relative frequency of cutaneous lymphoma (CL) have not been investigated in Asian populations. The aim of this study was to investigate the relative frequency, clinical characteristics, and survival outcomes of CL in Korean patients, and to evaluate the changes in relative frequency of CL over a 20-year period. The present retrospective cohort study included 395 patients, of whom 289 had primary CL and 106 secondary CL, seen at a tertiary referral hospital in Seoul, Korea. Primary CL included T-/NK-cell linage lymphoma (CTCL, 85.1%) and B-cell lineage lymphoma (CBCL, 14.9%). The relative frequency of CBCL increased over time, as shown by a decrease in the CTCL/CBCL ratio from 10.3 in 1994 to 2003 to 4.5 in 2004 to 2013. CTCL was more commonly associated with multiple and extensive skin lesions than CBCL. Extranodal NK/T-cell lymphoma and subcutaneous panniculitis-like T-cell lymphoma were commonly associated with extensive skin lesions. The 5-year overall survival rate for all patients with primary CL was 81%.
亚洲人群中皮肤淋巴瘤（CL）相对发病率的长期变化尚未得到研究。本研究旨在调查韩国患者CL的相对发病率、临床特征和生存结果，并评估20年间CL相对发病率的变化。本回顾性队列研究纳入了韩国首尔一家三级转诊医院的395例患者，其中289例为原发性CL，106例为继发性CL。原发性CL包括T-/NK细胞系淋巴瘤（CTCL，85.1%）和B细胞系淋巴瘤（CBCL，14.9%）。CBCL的相对发病率随时间增加，CTCL/CBCL比值从1994年至2003年的10.3降至2004年至2013年的4.5。与CBCL相比，CTCL更常与多发和广泛的皮肤病变相关。结外NK/T细胞淋巴瘤和皮下脂膜炎样T细胞淋巴瘤常与广泛的皮肤病变相关。所有原发性CL患者的5年总生存率为81%。
