Wang Yashuo, Bu Lingzhen, Yang Lili, Li Hongyan, Zhang Shicui
Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China; Department of Marine Biology, Ocean University of China, Qingdao 266003, China.
Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China.
Fish Shellfish Immunol. 2016 May;52:23-30. doi: 10.1016/j.fsi.2016.03.016. Epub 2016 Mar 11.
Fish-egg lectins (FELs) are identified in several species of fishes, but their activity and mode of action remain largely unknown in early life stages. Here we showed that zebrafish FEL (zFEL) was a maternal factor, which was capable of interacting with Gram-negative and Gram-positive bacteria and enhancing the phagocytosis of the bacteria by macrophages. Interestingly, microinjection of purified native zFEL into the embryos (resulting in the increase of zFEL in the embryos) markedly promoted the resistance of the embryos to the pathogenic Aeromonas hydrophila. Taken together, zFEL appears a maternal immune-relevant molecule capable of defending the developing embryos/larvae from pathogenic attacks.
鱼卵凝集素（FELs）在几种鱼类中被鉴定出来，但它们在早期生命阶段的活性和作用方式在很大程度上仍不清楚。在这里，我们表明斑马鱼FEL（zFEL）是一种母体因子，它能够与革兰氏阴性菌和革兰氏阳性菌相互作用，并增强巨噬细胞对细菌的吞噬作用。有趣的是，将纯化的天然zFEL显微注射到胚胎中（导致胚胎中zFEL增加）显著提高了胚胎对致病性嗜水气单胞菌的抵抗力。综上所述，zFEL似乎是一种与母体免疫相关的分子，能够保护发育中的胚胎/幼体免受病原体攻击。
