Campo J À, Merckelbach H L, Nijman H, Yeates-Frederikx M, Allertz W
Psychiatrisch Centrum Weiterhof te Heerlen.
Faculteit Psychologie van de Universiteit Maastricht.
Acta Neuropsychiatr. 2000 Dec;12(4):177-82. doi: 10.1017/S0924270800035353.
Skin conductance is a psychophysiological parameter that reflects fundamental processes such as attention and arousal. The present study explored whether deviations in skin conductance activity are associated with severity of schizophrenic symptoms. For this purpose, Skin Conductance Responses (SCRs) to discrete stimuli (80 dB noises) and Skin Conductance Levels (SCLs) of 37 schizophrenic patients and 31 healthy volunteers were recorded. In accordance with previous studies, schizophrenic patients were found to be hyporesponsive compared to healthy controls. More specifically, almost half of the patients (46%) did not react with any SCR to the first 3 stimuli, whereas only 10% of the control group exhibited such a non-responding. Accordingly, the mean amplitude of the first 3 SCRs - as measured in u Siemens - was found to be significantly lower in patients compared to controls. As well, mean SCL was found to be (marginally) elevated in the patient group. This was especially the case for patients who did exhibit SCRs. In the patient group, a negative correlation was found between amplitude of SCRs and symptom severity. This association was mainly carried by a significant correlation between positive symptoms and reduced SCRs. The clinical relevance of these findings is discussed in detail.
皮肤电传导是一种反映注意力和唤醒等基本过程的心理生理参数。本研究探讨了皮肤电传导活动的偏差是否与精神分裂症症状的严重程度相关。为此，记录了37名精神分裂症患者和31名健康志愿者对离散刺激（80分贝噪音）的皮肤电传导反应（SCRs）和皮肤电传导水平（SCLs）。与先前的研究一致，发现精神分裂症患者与健康对照组相比反应迟钝。更具体地说，几乎一半的患者（46%）对前3次刺激没有任何SCR反应，而对照组中只有10%表现出这种无反应。因此，与对照组相比，患者前3次SCR的平均幅度（以微西门子为单位测量）明显较低。此外，发现患者组的平均SCL（略有）升高。对于确实表现出SCRs的患者尤其如此。在患者组中，发现SCRs幅度与症状严重程度之间存在负相关。这种关联主要由阳性症状与SCRs降低之间的显著相关性所支撑。详细讨论了这些发现的临床意义。
