Müller M R, Linek M, Löwenstein C, Röthig A, Doucette K, Thorstensen K, Mueller R S
Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig-Maximilian University, Veterinärstraße 13, 80539 Munich, Germany.
Tierärztliche Spezialisten Hamburg, Rodigallee 85, 22043 Hamburg, Germany.
Vet J. 2016 Apr;210:77-81. doi: 10.1016/j.tvjl.2015.11.012. Epub 2015 Dec 1.
A randomised, double-blinded, placebo-controlled multicentre trial was conducted in 36 dogs with atopic dermatitis to evaluate the cyclosporine-sparing effect of polyunsaturated fatty acids. Dogs were stable on their individual cyclosporine dosage and received either a mainly omega-3 fatty acid product with a minor omega-6 fatty acid fraction or placebo, orally for 12 weeks. Dogs were examined every 4 weeks and the Canine Atopic Dermatitis Extent and Severity Index (CADESI-03) was determined by a clinician. Pruritus, quality of life, global condition and coat quality were scored by the owner. If the dog's CADESI-03 and/or pruritus score improved by at least 25% compared with the previous visit, the cyclosporine dosage was decreased by approximately 25%. If the scores deteriorated by at least 25%, the cyclosporine dosage was increased by the same percentage. The median daily cyclosporine dosage/kg bodyweight decreased in the active group from 4.1 mg to 2.6 mg and in the placebo group from 3.5 mg to 3.3 mg over the study period. The difference between the two groups was significant (P = 0.009). The improvement in median pruritus score from inclusion to completion was significantly greater in the active group than in the placebo group (P = 0.04). There was no significant difference in CADESI-03 changes between groups (P = 0.38). The results of this study indicate a cyclosporine-sparing effect of a mainly omega-3 fatty acid supplement in dogs with atopic dermatitis.
在36只患有特应性皮炎的犬只中进行了一项随机、双盲、安慰剂对照的多中心试验，以评估多不饱和脂肪酸对环孢素的节省作用。犬只在各自的环孢素剂量下病情稳定，口服主要含ω-3脂肪酸且含少量ω-6脂肪酸的产品或安慰剂，为期12周。每4周对犬只进行检查，由临床医生确定犬特应性皮炎范围和严重程度指数（CADESI-03）。瘙痒、生活质量、整体状况和被毛质量由犬主评分。如果犬只的CADESI-03和/或瘙痒评分较上次就诊时改善至少25%，则将环孢素剂量减少约25%。如果评分恶化至少25%，则将环孢素剂量增加相同百分比。在研究期间，活性组犬只每千克体重的环孢素日剂量中位数从4.1毫克降至2.6毫克，安慰剂组从3.5毫克降至3.3毫克。两组之间的差异具有显著性（P = 0.009）。从纳入研究到结束，活性组的瘙痒评分中位数改善幅度显著大于安慰剂组（P = 0.04）。两组之间CADESI-03的变化无显著差异（P = 0.38）。本研究结果表明，主要含ω-3脂肪酸的补充剂对患有特应性皮炎的犬只具有环孢素节省作用。
