Covington Les P, McCarrell Jamie, Hoerster Nicole S
Texas Tech University Health Sciences Center (TTUHSC) School of Pharmacy, Amarillo, Texas, USA.
Consult Pharm. 2016 Mar;31(3):168-74. doi: 10.4140/TCP.n.2016.168.
Evaluate the prevalence of anticholinergic medication use in the Program of All-Inclusive Care for the Elderly (PACE).
Cross-sectional, retrospective chart review.
The Basics at Jan Werner PACE, Amarillo, Texas.
PACE participants (n = 128) and long-term care residents (n = 105) 65 years of age and older.
The primary outcome was percentage of prescribed medications with anticholinergic properties and risk factors associated with prescribing: study site, gender, race, age, and creatinine clearance.
Anticholinergic medication prescribing was significantly lower in the PACE program (2.3% of total medications vs. 3.9%; P < 0.05) as well as total medication use (12.1 medications per subject vs. 20.8; P < 0.05 in the long-term care environment). Only the long-term care study site had a significant association with anticholinergic prescribing (odds ratio = 5.04, confidence interval 2.71-9.38). PACE participants also had lower Anticholinergic Risk Scale scores (score of 0, 60.2% PACE vs. 16.2%), reduced fall rates (23.8 per month PACE vs. 66.9), and similar hospitalization rates (5.4 per month PACE vs. 5.7).
PACE participants were prescribed fewer medications and had lower anticholinergic burden, which potentially lowers their risk of adverse effects. These data support the PACE interdisciplinary model by demonstrating the benefit of team care in appropriate use of medications. It provides a potential blueprint to organizations aimed at reducing potentially inappropriate medication prescribing in older adults.
评估老年全面照护计划(PACE)中抗胆碱能药物的使用情况。
横断面回顾性图表审查。
得克萨斯州阿马里洛的扬·维尔纳PACE基础机构。
65岁及以上的PACE参与者(n = 128)和长期护理居民(n = 105)。
主要结果是具有抗胆碱能特性的处方药物百分比以及与处方相关的风险因素:研究地点、性别、种族、年龄和肌酐清除率。
PACE计划中抗胆碱能药物的处方率显著较低(占总药物的2.3%,而长期护理机构为3.9%;P < 0.05),且总药物使用量也较低(每位受试者12.1种药物,长期护理环境中为20.8种;P < 0.05)。只有长期护理研究地点与抗胆碱能药物处方有显著关联(比值比 = 5.04,置信区间2.71 - 9.38)。PACE参与者的抗胆碱能风险量表得分也较低(得分为0,PACE组为60.2%,长期护理组为16.2%),跌倒率降低(PACE组每月23.8次,长期护理组为66.9次),住院率相似(PACE组每月5.4次,长期护理组为5.7次)。
PACE参与者的药物处方较少,抗胆碱能负担较低,这可能降低了他们出现不良反应的风险。这些数据通过证明团队护理在合理用药方面的益处,支持了PACE跨学科模式。它为旨在减少老年人潜在不适当药物处方的组织提供了一个潜在的蓝图。