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口腔缓释剂型的立体光刻(SLA)3D打印

Stereolithographic (SLA) 3D printing of oral modified-release dosage forms.

作者信息

Wang Jie, Goyanes Alvaro, Gaisford Simon, Basit Abdul W

机构信息

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1 N 1AX, UK.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1 N 1AX, UK; FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK.

出版信息

Int J Pharm. 2016 Apr 30;503(1-2):207-12. doi: 10.1016/j.ijpharm.2016.03.016. Epub 2016 Mar 11.

Abstract

The aim of this work was to evaluate the suitability of stereolithography (SLA) to fabricate drug-loaded tablets with modified-release characteristics. The SLA printer creates solid objects by using a laser beam to photopolymerise monomers. In this work polyethylene glycol diacrylate (PEGDA) was used as a monomer and diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide was used as a photo-initiator. 4-aminosalicylic acid (4-ASA) and paracetamol (acetaminophen) were selected as model drugs. Tablets were successfully printed and formulations with different properties were fabricated by adding polyethylene glycol 300 (PEG 300) to the printing solution. The loading of paracetamol and 4-ASA in the printed tablets was 5.69% and 5.40% respectively. In a realistic dynamic dissolution simulation of the gastrointestinal tract, drug release from the tablets was dependent on the composition of the formulations, but independent of dissolution pH. In conclusion SLA 3DP technology allows the manufacture of drug loaded tablets with specific extended-release profiles. In the future this technology could become a manufacturing technology for the elaboration of oral dosage forms, for industrial production or even for personalised dose.

摘要

这项工作的目的是评估立体光刻(SLA)制造具有缓释特性的载药片剂的适用性。SLA打印机通过使用激光束使单体光聚合来创建固体物体。在这项工作中,聚乙二醇二丙烯酸酯(PEGDA)被用作单体,二苯基(2,4,6-三甲基苯甲酰基)氧化膦被用作光引发剂。选择4-氨基水杨酸(4-ASA)和对乙酰氨基酚(扑热息痛)作为模型药物。通过向打印溶液中添加聚乙二醇300(PEG 300)成功打印出片剂并制备了具有不同性质的制剂。打印片剂中对乙酰氨基酚和4-ASA的载量分别为5.69%和5.40%。在胃肠道的实际动态溶解模拟中,片剂中的药物释放取决于制剂的组成,但与溶解pH无关。总之,SLA 3DP技术允许制造具有特定缓释曲线的载药片剂。未来,这项技术可能成为用于制备口服剂型、工业生产甚至个性化剂量的制造技术。

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