Białek Antoni, Krysztofiak Julia, Hozakowska Aleksandra, Wojszel Zuzanna, Osmałek Tomasz, Wojtyłko Monika, Froelich Anna
Student's Research Group of Pharmaceutical Technology, The Student Scientific Society of Poznan University of Medical Sciences, 5 Rokietnicka Street, 60-806 Poznań, Poland.
Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznań, Poland.
Gels. 2025 Mar 8;11(3):187. doi: 10.3390/gels11030187.
Over the past years, numerous novel dosage forms, including gels, have been investigated for paediatric treatment due to the need to provide flexible dose adjustment possibilities, as well as a patient-friendly approach to drug delivery. Simultaneously, 3D printing technology is continuously advancing and gaining interest as a tool for personalised formulation development. Multiple additive manufacturing methods, including the semi-solid extrusion, especially used in gel printing, provide flexibility regarding the dose of active ingredients and the adjustment of the design of soft dosage forms. 3D printing techniques can be considered as a possible answer to the demand for medicines tailored to small patients' needs. This review intends to present an overview of the current possibilities, comparing gel-like and non-gel-formulated dosage forms and crucial aspects of developing those cutting-edge dosage forms by 3D printing. This paper discusses soft formulations such as chewing gums, which still require extensive evaluation, and explores the question of the three-dimensional printing process. Furthermore, it highlights soft dosage forms, such as gel-based gummies and hydrogels, for which 3D fabrication has been intensively studied in previous years. However, the research still needs to advance.
在过去几年中，由于需要提供灵活的剂量调整可能性以及采用对患者友好的药物递送方式，包括凝胶在内的众多新型剂型已被用于儿科治疗研究。与此同时，3D打印技术不断进步，并作为个性化制剂开发工具受到关注。多种增材制造方法，包括特别用于凝胶打印的半固体挤出法，在活性成分剂量和软质剂型设计调整方面具有灵活性。3D打印技术可被视为满足小患者用药需求的一种可能解决方案。本综述旨在概述当前的可能性，比较凝胶状和非凝胶状剂型以及通过3D打印开发这些前沿剂型的关键方面。本文讨论了仍需广泛评估的软质制剂，如口香糖，并探讨了三维打印过程的问题。此外，还重点介绍了软质剂型，如基于凝胶的软糖和水凝胶，前几年对其3D制造进行了深入研究。然而，研究仍需推进。
