UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.
Int J Pharm. 2016 Oct 30;512(2):355-359. doi: 10.1016/j.ijpharm.2016.03.017. Epub 2016 Mar 11.
Paediatrics and geriatrics both represent highly heterogenous populations and require special consideration when developing appropriate dosage forms. This paper discusses similarities, differences and considerations with respect to the development of appropriate medicine formulations for paediatrics and geriatrics. Arguably the most significant compliance challenge in older people is polypharmacy, whereas for children the largest barrier is taste. Pharmaceutical technology has progressed rapidly and technologies including FDCs, multi-particulates and orodispersible dosage forms provide unprecedented opportunities to develop novel and appropriate formulations for both old and new drugs. However, it is important for the formulation scientists to work closely with patients, carers and clinicians to develop such formulations for both the paediatric and geriatric population.
儿科学和老年医学都代表着高度异质的人群，在开发合适的剂型时需要特别考虑。本文讨论了在为儿科和老年医学开发合适的药物制剂方面的相似之处、差异和注意事项。可以说，老年人最显著的用药合规性挑战是多药治疗，而对于儿童来说，最大的障碍是口味。药物制剂技术发展迅速，包括固定剂量复方制剂、多颗粒制剂和口腔崩解片等技术，为开发新旧药物的新型和合适制剂提供了前所未有的机会。然而，对于制剂科学家来说，重要的是与患者、护理人员和临床医生密切合作，为儿科和老年人群开发此类制剂。
