Raje Vishvesh, Palekar Siddhant, Banella Sabrina, Patel Ketan
College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA.
Pharmaceutics. 2022 Oct 14;14(10):2192. doi: 10.3390/pharmaceutics14102192.
Three-dimensional (3D) printing is proving to be a pivotal technology for developing personalized dosage forms with bench to bedside feasibility. Fused deposition modelling (FDM) 3D printing has emerged as the most used technique wherein molten drug-loaded polymer filaments are deposited layer-by-layer to fabricate a predefined shape and internal geometry. However, for precise FDM 3D printing, it is imperative for the filaments to have peculiar mechanical/physicochemical properties, which the majority of the FDA/GRAS approved polymers lack. In the current study, a novel water-soluble polymer, Poly(2-ethyl-tetra-oxazoline) [PETOx] has been investigated as an extrudable and printable polymer with two different types of drug molecule—dextromethorphan hydrobromide (DXM) and hydrochlorothiazide (HCTZ). Hot-stage microscopy experiments of drug:polymer (1:1 w/w) and filaments were carried out at 25−275 °C. HCTZ-loaded filament showed higher toughness of 17 ± 3.25 × 106 J/m3 compared with DXM and drug-free filament. Moisture sorption and flexural analysis was performed to understand the correlation of mechanical properties and storage humidity to printability. Varying the number of outer perimeters of each layer (shell number) was observed to affect the drug release pattern from the printlets. The DXM one-shell printlet showed >80%, whereas the DXM five-shell printlet showed >60% of the drug release within 60 min. PETOx could prove to be a high-performance and versatile 3D printable polymer.
三维（3D）打印正被证明是一种用于开发具有从实验室到床边可行性的个性化剂型的关键技术。熔融沉积建模（FDM）3D打印已成为最常用的技术，其中将载有药物的熔融聚合物长丝逐层沉积以制造预定义的形状和内部几何结构。然而，对于精确的FDM 3D打印，长丝必须具有特殊的机械/物理化学性质，而大多数FDA/GRAS批准的聚合物缺乏这些性质。在当前的研究中，一种新型水溶性聚合物聚（2-乙基-四恶唑啉）[PETOx]已被研究作为一种可挤出和可打印聚合物，用于两种不同类型的药物分子——氢溴酸右美沙芬（DXM）和氢氯噻嗪（HCTZ）。在25−275°C下对药物：聚合物（1:1 w/w）和长丝进行了热台显微镜实验。与DXM和无药物长丝相比，载有HCTZ的长丝显示出更高的韧性，为17±3.25×106 J/m3。进行了水分吸附和弯曲分析，以了解机械性能和储存湿度与可打印性之间的相关性。观察到改变每层的外周数量（壳层数）会影响小打印件的药物释放模式。DXM单壳小打印件在60分钟内显示>80%的药物释放，而DXM五壳小打印件在60分钟内显示>60%的药物释放。PETOx可能被证明是一种高性能且通用的3D可打印聚合物。
