干细胞与可注射水凝胶：心肌修复中的协同治疗策略。
Stem cells and injectable hydrogels: Synergistic therapeutics in myocardial repair.
机构信息
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Metallurgy and Materials Engineering, Faculty of Engineering, University of Semnan, Semnan, Iran.
Department of Genetics, Islamic Azad University, Tehran Medical Branch, Tehran, Iran.
出版信息
Biotechnol Adv. 2016 Jul-Aug;34(4):362-379. doi: 10.1016/j.biotechadv.2016.03.003. Epub 2016 Mar 11.
One of the major problems in the treatment of cardiovascular diseases is the inability of myocardium to self-regenerate. Current therapies are unable to restore the heart's function after myocardial infarction. Myocardial tissue engineering is potentially a key approach to regenerate damaged heart muscle. Myocardial patches are applied surgically, whereas injectable hydrogels provide effective minimally invasive approaches to recover functional myocardium. These hydrogels are easily administered and can be either cell free or loaded with bioactive agents and/or cardiac stem cells, which may apply paracrine effects. The aim of this review is to investigate the advantages and disadvantages of injectable stem cell-laden hydrogels and highlight their potential applications for myocardium repair.
心血管疾病治疗中的一个主要问题是心肌无法自我再生。目前的治疗方法无法在心肌梗死后恢复心脏功能。心肌组织工程是一种潜在的关键方法，可以再生受损的心肌。心肌贴片通过手术应用，而可注射水凝胶则提供了恢复功能性心肌的有效微创方法。这些水凝胶易于给药，既可以是无细胞的，也可以负载生物活性物质和/或心脏干细胞，从而发挥旁分泌作用。本综述的目的是研究可注射干细胞负载水凝胶的优缺点，并强调其在心梗治疗中的潜在应用。
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