Abubakar Muhammad, Masood Muhammad Faiq, Javed Izzah, Adil Hira, Faraz Muhammad Ahmad, Bhat Rakshita Ramesh, Fatima Mahek, Abdelkhalek Ahmad M, Buccilli Barbara, Raza Saud, Hajjaj Mohsin
Department of Internal Medicine, Ameer-Ud-Din Medical College, Lahore General Hospital, Lahore, PAK.
Department of Internal Medicine, Siddique Sadiq Memorial Trust Hospital, Gujranwala, PAK.
Cureus. 2023 Jul 7;15(7):e41533. doi: 10.7759/cureus.41533. eCollection 2023 Jul.
Revolutionary advancements in regenerative medicine have brought stem cell therapy to the forefront, offering promising prospects for the regeneration of ischemic cardiac tissue. Yet, its full efficacy, safety, and role in treating ischemic heart disease (IHD) remain limited. This literature review explores the intricate mechanisms underlying stem cell therapy. Furthermore, we unravel the innovative approaches employed to bolster stem cell survival, enhance differentiation, and seamlessly integrate them within the ischemic cardiac tissue microenvironment. Our comprehensive analysis uncovers how stem cells enhance cell survival, promote angiogenesis, and modulate the immune response. Stem cell therapy harnesses a multifaceted mode of action, encompassing paracrine effects and direct cell replacement. As our review progresses, we underscore the imperative for standardized protocols, comprehensive preclinical and clinical studies, and careful regulatory considerations. Lastly, we explore the integration of tissue engineering and genetic modifications, envisioning a future where stem cell therapy reigns supreme in regenerative medicine.
再生医学的革命性进展已将干细胞疗法推到前沿，为缺血性心脏组织的再生带来了充满希望的前景。然而，其在治疗缺血性心脏病（IHD）方面的全面疗效、安全性和作用仍然有限。这篇文献综述探讨了干细胞疗法背后的复杂机制。此外，我们还揭示了为提高干细胞存活率、增强分化并使其无缝融入缺血性心脏组织微环境而采用的创新方法。我们的综合分析揭示了干细胞如何增强细胞存活、促进血管生成并调节免疫反应。干细胞疗法采用多方面的作用模式，包括旁分泌效应和直接细胞替代。随着我们综述的推进，我们强调标准化方案、全面的临床前和临床研究以及谨慎的监管考量的必要性。最后，我们探讨组织工程和基因修饰的整合，展望干细胞疗法在再生医学中占据主导地位的未来。
