Department of Advanced Materials Engineering, Chung-Ang University, Anseong, 17546, Republic of Korea.
Department of Intelligence Energy and Industry, Chung-Ang University, Seoul, 06974, Republic of Korea.
Adv Sci (Weinh). 2023 Sep;10(27):e2303429. doi: 10.1002/advs.202303429. Epub 2023 Jul 30.
Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell-derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio-interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.
心肌梗死（MI）是导致死亡和残疾的主要原因之一。最近开发的心脏补片为 MI 区域提供机械支撑和额外的导电路径，以促进电信号的传播，从而实现心脏兴奋和收缩的同步。基于导电聚合物的心脏补片具有吸引人的特性；然而，弹性水平适中以及高阻抗界面限制了它们的机械和电气性能。这些结构即使在它们的用途仅限于 MI 引起的组织损伤的愈合期的情况下，也作为永久性植入物运行。这里介绍的工作提出了一种高导电性的心脏补片，它将生物可吸收金属和聚合物结合在一个薄蛇形几何形状的混合材料结构中，具有弹性机械性能。有限元分析指导这些系统中布局的优化选择。在心脏补片上培养的人诱导多能干细胞衍生的心肌细胞的规则和同步收缩以及体外研究为基本特性和生物界面提供了深入的见解。这些结果为治疗 MI 和其他心脏疾病的心脏补片设计提供了更多选择。
