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用于精准心血管护理和临床研究的即时检测技术：美国国立心肺血液研究所工作组

Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research: National Heart, Lung, and Blood Institute Working Group.

作者信息

King Kevin, Grazette Luanda P, Paltoo Dina N, McDevitt John T, Sia Samuel K, Barrett Paddy M, Apple Fred S, Gurbel Paul A, Weissleder Ralph, Leeds Hilary, Iturriaga Erin J, Rao Anupama, Adhikari Bishow, Desvigne-Nickens Patrice, Galis Zorina S, Libby Peter

机构信息

Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California.

出版信息

JACC Basic Transl Sci. 2016 Jan-Feb;1(1-2):73-86. doi: 10.1016/j.jacbts.2016.01.008.

DOI:10.1016/j.jacbts.2016.01.008
PMID:26977455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4787294/
Abstract

Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a working group to discuss POCT in cardiovascular medicine. The multidisciplinary working group, which included clinicians, scientists, engineers, device manufacturers, regulatory officials, and program staff, reviewed the state of the POCT field; discussed opportunities for POCT to improve cardiovascular care, realize the promise of precision medicine, and advance the clinical research enterprise; and identified barriers facing translation and integration of POCT with existing clinical systems. A POCT development roadmap emerged to guide multidisciplinary teams of biomarker scientists, technologists, health care providers, and clinical trialists as they: 1) formulate needs assessments; 2) define device design specifications; 3) develop component technologies and integrated systems; 4) perform iterative pilot testing; and 5) conduct rigorous prospective clinical testing to ensure that POCT solutions have substantial effects on cardiovascular care.

摘要

即时检测技术（POC或POCT）正在推动创新的心血管诊断，有望在各种临床环境中改善患者护理。美国国立心肺血液研究所召集了一个工作组来讨论心血管医学中的POC技术。这个多学科工作组包括临床医生、科学家、工程师、设备制造商、监管官员和项目工作人员，他们审查了POC技术领域的现状；讨论了POC技术改善心血管护理、实现精准医学的前景以及推进临床研究事业的机会；并确定了POC技术与现有临床系统的转化和整合所面临的障碍。由此产生了一个POC技术发展路线图，以指导生物标志物科学家、技术专家、医疗保健提供者和临床试验人员组成的多学科团队开展以下工作：1）制定需求评估；2）定义设备设计规格；3）开发组件技术和集成系统；4）进行迭代试点测试；5）进行严格的前瞻性临床测试，以确保POC技术解决方案对心血管护理产生重大影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/54f96570b0d8/gr6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/983c6c8f4795/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/54f96570b0d8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/628ff4b58220/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/75051dfe1f3e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/d76539e4e4e7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/a430eb0bcc85/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/983c6c8f4795/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e7f/6113161/54f96570b0d8/gr6.jpg

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