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MKP1: Jekyll and Hyde for E1A.

作者信息

Cimas Francisco J, Callejas-Valera Juan Callejas-Valera Luis, Sanchez-Prieto Ricardo

机构信息

Unidad de Medicina Molecular, Laboratorio de Oncología, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 02006, Albacete, Spain.

出版信息

Aging (Albany NY). 2016 Feb;8(2):214-5. doi: 10.18632/aging.100918.

DOI:10.18632/aging.100918
PMID:26977801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4789577/
Abstract
摘要

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MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells.MKP1介导E1a在非小细胞肺癌细胞中对顺铂的化学增敏作用。
Oncotarget. 2015 Dec 29;6(42):44095-107. doi: 10.18632/oncotarget.6574.
2
Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance.挖掘自噬在顺铂治疗中的潜力：一种克服耐药性的新策略。
Oncotarget. 2015 Jun 20;6(17):15551-65. doi: 10.18632/oncotarget.3902.
3
Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.p38MAPK 的抑制作用使肿瘤细胞对活性氧和 JNK 介导的顺铂诱导的细胞凋亡敏感。
EMBO Mol Med. 2013 Nov;5(11):1759-74. doi: 10.1002/emmm.201302732. Epub 2013 Sep 24.
4
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer.丝裂原活化蛋白（MAP）激酶/ MAP激酶磷酸酶调控：在细胞生长、死亡及癌症中的作用
Pharmacol Rev. 2008 Sep;60(3):261-310. doi: 10.1124/pr.107.00106.
5
E1a gene expression blocks the ERK1/2 signaling pathway by promoting nuclear localization and MKP up-regulation: implication in v-H-Ras-induced senescence.E1a基因表达通过促进核定位和上调MKP来阻断ERK1/2信号通路：对v-H-Ras诱导的衰老的影响
J Biol Chem. 2008 May 9;283(19):13450-8. doi: 10.1074/jbc.M709230200. Epub 2008 Mar 3.
6
ERK-dependent MKP-1-mediated cisplatin resistance in human ovarian cancer cells.人卵巢癌细胞中ERK依赖性MKP-1介导的顺铂耐药性
Cancer Res. 2007 Dec 15;67(24):11933-41. doi: 10.1158/0008-5472.CAN-07-5185.
7
Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma.丝裂原活化蛋白激酶磷酸酶-1（MKP-1）在原发性人卵巢癌中的表达。
Int J Cancer. 2002 Dec 10;102(5):507-13. doi: 10.1002/ijc.10746.