选择性靶向 KRAS G12C 突变：趁 KRAS 虚弱时打击它。
Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down.
机构信息
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Department of Structural Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
出版信息
Cancer Cell. 2016 Mar 14;29(3):251-253. doi: 10.1016/j.ccell.2016.02.015.
PMID:26977877
Abstract
Two recent studies evaluated a small molecule that specifically binds to and inactivates the KRAS G12C mutant. The new findings argue that the perception that mutant KRAS is persistently frozen in its active GTP-bound form may not be accurate.
摘要
最近的两项研究评估了一种小分子，该小分子特异性结合并失活 KRAS G12C 突变体。新的发现表明，突变型 KRAS 一直处于其活性 GTP 结合形式的这种观点可能并不准确。
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