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[全胰切除术后糖尿病患者的治疗问题]

[Therapeutic problems of patients with diabetes mellitus after total pancreatectomy].

作者信息

Bak M

出版信息

Pol Arch Med Wewn. 1989 Mar;81(3):137-43.

PMID:2697866
Abstract

Followed were 11 patients after total pancreatectomy (for carcinoma--6 patients, for sequelae of the chronic pancreatitis--5 patients), aged 52-62 years. The follow-up period ranged 5 months up to 4 years. All pacreatomized patients had diabetes needing insulin administration, although the need for insulin decreased with time down to 16-40 units/24 hours after one year. The diabetes was rather brittle with high incidence of hypoglycaemia. In 7 patients keeping exact records the incidence of hypoglycaemic events was 16-24 within the first month, 9-16 in the third month following pancreatectomy. In two patients death was due to the severe hypoglycaemia developing in the later postoperative period. The observations call for a necessary "intensive metabolic care" of every patient, totally pancreatomised. This intensive metabolic care must include not only careful instructing the patients but also his or her family how to behave in a totally different metabolic condition of the patient. Self-control, including blood sugar estimation several times a day gets special importance.

摘要

接下来是11例全胰切除术后的患者(6例因癌症,5例因慢性胰腺炎后遗症),年龄在52至62岁之间。随访时间为5个月至4年。所有接受胰腺切除的患者均患有糖尿病,需要注射胰岛素,尽管随着时间推移,胰岛素需求量在一年后降至16至40单位/24小时。糖尿病病情相当不稳定,低血糖发生率较高。在7例详细记录的患者中,低血糖事件的发生率在全胰切除术后第一个月为16至24次,第三个月为9至16次。两名患者死于术后晚期发生的严重低血糖。这些观察结果表明,对于每一位接受全胰切除的患者,都需要进行必要的“强化代谢护理”。这种强化代谢护理不仅必须包括仔细指导患者及其家人如何在患者完全不同的代谢状况下应对,自我监测,包括每天多次进行血糖测定,具有特别重要的意义。

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1
[Therapeutic problems of patients with diabetes mellitus after total pancreatectomy].[全胰切除术后糖尿病患者的治疗问题]
Pol Arch Med Wewn. 1989 Mar;81(3):137-43.
2
Retrospective review of postoperative glycemic control in patients after distal pancreatectomy.回顾性分析远端胰腺切除术后患者的术后血糖控制情况。
Int J Surg. 2017 May;41:86-90. doi: 10.1016/j.ijsu.2017.03.060. Epub 2017 Mar 24.
3
Parenteral nutrition and insulin per protocol improve diabetes management after total pancreatectomy.按照方案进行肠外营养和胰岛素治疗可改善全胰切除术后的糖尿病管理。
Dan Med J. 2018 Apr;65(4).
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Management of secondary diabetes mellitus after total pancreatectomy in infancy.婴儿期全胰切除术后继发性糖尿病的管理。
Arch Dis Child. 1984 Apr;59(4):356-9. doi: 10.1136/adc.59.4.356.
5
Increase in postoperative insulin requirements does not lead to decreased quality of life after total pancreatectomy with islet cell autotransplantation for chronic pancreatitis.对于慢性胰腺炎患者,在接受全胰切除术并进行胰岛细胞自体移植后,术后胰岛素需求量增加并不会导致生活质量下降。
Am Surg. 2013 Jul;79(7):676-80.
6
[Incidence of severe hypoglycemia in relation to metabolic control and patient knowledge].[严重低血糖与代谢控制及患者知识的相关性发病率]
Med Klin (Munich). 1995 Oct 15;90(10):557-61.
7
[Pancreatectomy and diabetes].[胰腺切除术与糖尿病]
Ann Chir. 1999;53(5):406-11.
8
Metabolic and target organ outcomes after total pancreatectomy: Mayo Clinic experience and meta-analysis of the literature.全胰切除术后的代谢和靶器官结局:Mayo 诊所的经验和文献荟萃分析。
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[A case of unstable diabetes mellitus after total pancreatectomy controlled by CSII].[全胰切除术后采用持续皮下胰岛素输注控制的不稳定型糖尿病病例]
Fukuoka Igaku Zasshi. 1991 Aug;82(8):467-9.
10
Successful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report.胰岛同种异体移植成功治疗全胰切除术后脆性糖尿病:一例报告
JOP. 2013 Jul 10;14(4):428-31. doi: 10.6092/1590-8577/1440.