Taghavi Sharven, Jayarajan Senthil N, Ambur Vishnu, Mangi Abeel A, Chan Elaine, Dauer Elizabeth, Sjoholm Lars O, Pathak Abhijit, Santora Thomas A, Goldberg Amy J, Rappold Joseph F
From the *Department of Surgery, Temple University School of Medicine, Philadelphia, Pennsylvania; †Division of Cardiothoracic Surgery, Department of Surgery; and ‡Section of Vascular Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, Missouri; and §Department of Cardiac Surgery, Yale University School of Medicine, New Haven, Connecticut.
ASAIO J. 2016 Jul-Aug;62(4):370-4. doi: 10.1097/MAT.0000000000000366.
As left ventricular assist devices (LVADs) are increasingly used for patients with end-stage heart failure, the need for noncardiac surgical procedures (NCSs) in these patients will continue to rise. We examined the various types of NCS required and its outcomes in LVAD patients requiring NCS. The National Inpatient Sample Database was examined for all patients implanted with an LVAD from 2007 to 2010. Patients requiring NCS after LVAD implantation were compared to all other patients receiving an LVAD. There were 1,397 patients undergoing LVAD implantation. Of these, 298 (21.3%) required 459 NCS after LVAD implantation. There were 153 (33.3%) general surgery procedures, with abdominal/bowel procedures (n = 76, 16.6%) being most common. Thoracic (n = 141, 30.7%) and vascular (n = 140, 30.5%) procedures were also common. Patients requiring NCS developed more wound infections (9.1 vs. 4.6%, p = 0.004), greater bleeding complications (44.0 vs. 24.8%, p < 0.001) and were more likely to develop any complication (87.2 vs. 82.0%, p = 0.001). On multivariate analysis, the requirement of NCSs (odds ratio: 1.45, 95% confidence interval: 0.95-2.20, p = 0.08) was not associated with mortality. Noncardiac surgical procedures are commonly required after LVAD implantation, and the incidence of complications after NCS is high. This suggests that patients undergoing even low-risk NCS should be cared at centers with treating surgeons and LVAD specialists.
随着左心室辅助装置(LVAD)越来越多地用于终末期心力衰竭患者,这些患者对非心脏外科手术(NCS)的需求将持续增加。我们研究了LVAD患者所需的各种类型的NCS及其结果。对2007年至2010年所有植入LVAD的患者的国家住院样本数据库进行了检查。将LVAD植入后需要NCS的患者与所有其他接受LVAD的患者进行比较。共有1397例患者接受了LVAD植入。其中,298例(21.3%)在LVAD植入后需要进行459次NCS。有153例(33.3%)为普通外科手术,其中腹部/肠道手术(n = 76,16.6%)最为常见。胸部手术(n = 141,30.7%)和血管手术(n = 140,30.5%)也很常见。需要NCS的患者发生更多的伤口感染(9.1%对4.6%,p = 0.004)、更多的出血并发症(44.0%对24.8%,p < 0.001),并且更有可能发生任何并发症(87.2%对82.0%,p = 0.001)。多变量分析显示,NCS的需求(比值比:1.45,95%置信区间:0.95 - 2.20,p = 0.08)与死亡率无关。LVAD植入后通常需要进行非心脏外科手术,且NCS后并发症的发生率很高。这表明,即使是接受低风险NCS的患者也应由有治疗经验的外科医生和LVAD专家在中心进行护理。