Spalek K, Coynel D, Freytag V, Hartmann F, Heck A, Milnik A, de Quervain D, Papassotiropoulos A
Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.
Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland.
Transl Psychiatry. 2016 Mar 15;6(3):e758. doi: 10.1038/tp.2016.20.
Dysregulation of emotional arousal is observed in many psychiatric diseases such as schizophrenia, mood and anxiety disorders. The neurotrophic tyrosine kinase receptor type 2 gene (NTRK2) has been associated with these disorders. Here we investigated the relation between genetic variability of NTRK2 and emotional arousal in healthy young subjects in two independent samples (n1=1171; n2=707). In addition, diffusion tensor imaging (DTI) data in a subgroup of 342 participants were used to identify NTRK2-related white-matter structure differences. After correction for multiple testing, we identified a NTRK2 single nucleotide polymorphism associated with emotional arousal in both samples (n1: Pnominal=0.0003, Pcorrected=0.048; n2: Pnominal=0.0141, Pcorrected=0.036). DTI revealed significant, whole-brain corrected correlations between emotional arousal and brain white-matter mean diffusivity (MD), as well as significant, whole-brain corrected NTRK2 genotype-related differences in MD (PFWE<0.05). Our study demonstrates that genetic variability of NTRK2, a susceptibility gene for psychiatric disorders, is related to emotional arousal and-independently-to brain white-matter properties in healthy individuals.
在许多精神疾病如精神分裂症、情绪和焦虑症中都观察到了情绪唤起的失调。神经营养性酪氨酸激酶受体2型基因（NTRK2）与这些疾病有关。在此，我们在两个独立样本（n1 = 1171；n2 = 707）中研究了健康年轻受试者中NTRK2的基因变异性与情绪唤起之间的关系。此外，我们使用了342名参与者亚组的扩散张量成像（DTI）数据来识别与NTRK2相关的白质结构差异。在进行多重检验校正后，我们在两个样本中均发现了一个与情绪唤起相关的NTRK2单核苷酸多态性（n1：名义P值 = 0.0003，校正后P值 = 0.048；n2：名义P值 = 0.0141，校正后P值 = 0.036）。DTI显示情绪唤起与脑白质平均扩散率（MD）之间存在显著的全脑校正相关性，以及MD中与NTRK2基因型相关的显著全脑校正差异（家族性错误率校正P值<0.05）。我们的研究表明，作为精神疾病易感基因的NTRK2的基因变异性与健康个体的情绪唤起相关，并且独立于脑白质特性。
