Tu Peng-fei, Jiang Yong, Guo Xiao-yu
Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(17):3423-8.
Referring to the rapid developed life science and the higher requirements for the approval of innovative Chinese drugs in recent years, this paper described systematically the discovery, research and development (R&D) approaches for the innovative Chinese drugs under the new situation from the following five aspects, i. e., active components discovered from TCMs, the discovery of effective fractions of TCMs and their formulae, the R&D of TCM innovative drugs based on famous classic prescriptions and famous Chinese patent drugs, and the transformation of clinical effective prescriptions, on the basis of analysing the advantages of innovative drugs derived from natural products based on TCM theories and the problems existed in current R&D of new TCM drugs. Moreover, five suggestions are also given for the rapid development of TCM innovative drugs in China. All these will provide reference for the R&D of TCM innovative drugs.
针对近年来快速发展的生命科学以及对创新中药审批的更高要求，本文在分析基于中医理论的天然产物创新药物优势及当前中药新药研发存在问题的基础上，从以下五个方面系统阐述了新形势下创新中药的发现、研究与开发（R&D）途径，即从中药中发现活性成分、发现中药及其方剂的有效部位、基于著名经典方剂和著名中成药研发中药创新药物、临床有效方剂的转化，并对我国中药创新药物的快速发展提出了五条建议，为中药创新药物的研发提供参考。
