Malamut Georgia, Cellier Christophe
Rev Prat. 2015 Dec;65(10):1299-304.
Celiac disease is an inflammatory enteropathy, autoimmune-like, due to gluten intake in genetically predisposed persons with HLA-DQ2/DQ8 genotyping. Prevalence rates are approaching 1% of population in Europe and USA. Clinical expression of celiac disease is extremely various. Screening is based on detection of serum celiac antibodies and diagnosis is confirmed with duodenal biopsy. Treatment relies on gluten free diet (GFD) with eviction of wheat, barley and rye. GFD allows prevention of osteopenia, autoimmune diseases and malignant complications. The main cause of resistance to GFD because is its bad observance.
乳糜泻是一种炎症性肠病，类似自身免疫性疾病，由具有HLA-DQ2/DQ8基因分型的遗传易感性个体摄入麸质引起。在欧洲和美国，患病率接近人口的1%。乳糜泻的临床表现极为多样。筛查基于血清乳糜泻抗体的检测，十二指肠活检可确诊。治疗依赖于无麸质饮食（GFD），即排除小麦、大麦和黑麦。GFD可预防骨质减少、自身免疫性疾病和恶性并发症。对GFD产生抵抗的主要原因是其依从性差。
