Suwala Abigail K, Hanaford Allison, Kahlert Ulf D, Maciaczyk Jaroslaw
From the Department of Neurosurgery, University Medical Center Düsseldorf, Düsseldorf, Germany (AKS, UDK, JM); and Division of Neuropathology, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland (AH).
J Neuropathol Exp Neurol. 2016 May;75(5):388-96. doi: 10.1093/jnen/nlw013. Epub 2016 Mar 15.
Glioblastoma (GBM) is the most malignant brain tumor and has a dismal prognosis. Aberrant WNT signaling is known to promote glioma cell growth and dissemination and resistance to conventional radio- and chemotherapy. Moreover, a population of cancer stem-like cells that promote glioma growth and recurrence are strongly dependent on WNT signaling. Here, we discuss the role and mechanisms of aberrant canonical and noncanonical WNT signaling in GBM. We present current clinical approaches aimed at modulating WNT activity and evaluate their clinical perspective as a novel treatment option for GBM.
胶质母细胞瘤（GBM）是最恶性的脑肿瘤，预后不佳。已知异常的WNT信号传导可促进胶质瘤细胞的生长、扩散以及对传统放疗和化疗的耐药性。此外，促进胶质瘤生长和复发的癌干细胞群体强烈依赖WNT信号传导。在此，我们讨论异常的经典和非经典WNT信号传导在GBM中的作用和机制。我们介绍了目前旨在调节WNT活性的临床方法，并评估它们作为GBM新型治疗选择的临床前景。
