胶质瘤上皮-间质转化的新趋势与研究热点：科学计量学分析与综述
Emerging trends and research foci of epithelial-mesenchymal transition in gliomas: A scientometric analysis and review.
作者信息
Xing Yang, He Minghua, Su Zhenjin, Yasinjan Feroza, Liu Jiankai, Wang Hong, Cui Jiayue, Hong Xinyu
机构信息
Department of Neurosurgery, The First Hospital of Jilin University, Chang Chun, China.
College of Computer Science and Technology, Jilin University, Chang Chun, China.
出版信息
Front Oncol. 2022 Oct 20;12:1015236. doi: 10.3389/fonc.2022.1015236. eCollection 2022.
BACKGROUND
Epithelial-mesenchymal transition (EMT) is a key factor in the invasion and migration of glioma cells, and the study of EMT in gliomas has become a hot topic over the past decade. Scientometric analysis is gaining more attention since it can obtain hot topics and emerging trends in a research field. This article analyzed the research related to EMT in gliomas for the first time, including descriptions of research situations, evaluations of research foci, and predictions of emerging trends.
METHODS
We searched the topic-related original articles from January 2012 to December 2021 in the Web of Science Core Collection (WoSCC) by using a specific strategy, and a total of 1,217 publications were obtained. The WoS platform, VOS viewer, and CiteSpace were used to analyze the annual distribution of publications and citations, authors and density of keywords, and other analyses including countries, institutions, references, clustering, burst analysis, and the timeline view of keywords.
RESULTS
Scientometric analysis identified that the study of EMT in gliomas has developed fast and received continuous attention in the last decade. Based on the results of data analysis, most publications on the topic came from China, and the United States had the highest betweenness centrality. The top 10 co-cited references revealed the landmark documents that had greatly promoted the development of this field. The major focus is on the cellular and molecular mechanisms of EMT in gliomas, and the therapy related to EMT target and non-coding RNAs has been developing fast in recent years.
CONCLUSIONS
This study revealed the intimate connections between EMT and gliomas, and the complex mechanisms regulating EMT in gliomas had been studied widely in the last decade. Exploring the deep mechanisms of EMT in gliomas is the foundation of the targeted inhibitions, which can promote the development of therapies for gliomas.
背景
上皮-间质转化（EMT）是胶质瘤细胞侵袭和迁移的关键因素，在过去十年中，胶质瘤中EMT的研究已成为热门话题。科学计量分析越来越受到关注，因为它可以获取一个研究领域的热点话题和新兴趋势。本文首次分析了与胶质瘤中EMT相关的研究，包括研究情况描述、研究热点评估以及新兴趋势预测。
方法
我们采用特定策略在Web of Science核心合集（WoSCC）中检索了2012年1月至2021年12月期间与该主题相关的原始文章，共获得1217篇出版物。使用WoS平台、VOSviewer和CiteSpace分析出版物和引文的年度分布、作者和关键词密度，以及包括国家、机构、参考文献、聚类、突现分析和关键词时间线视图在内的其他分析。
结果
科学计量分析表明，胶质瘤中EMT的研究在过去十年中发展迅速且持续受到关注。基于数据分析结果，该主题的大多数出版物来自中国，美国的中介中心性最高。前10篇共被引参考文献揭示了极大推动该领域发展的标志性文献。主要重点是胶质瘤中EMT的细胞和分子机制，近年来与EMT靶点和非编码RNA相关的治疗发展迅速。
结论
本研究揭示了EMT与胶质瘤之间的密切联系，在过去十年中已广泛研究了胶质瘤中调节EMT的复杂机制。探索胶质瘤中EMT的深层机制是靶向抑制的基础，可促进胶质瘤治疗的发展。
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