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表皮朗格汉斯细胞与树突状细胞之间的结构和功能关系。

Structural and functional relationships between epidermal Langerhans cells and dendritic cells.

作者信息

Romani N, Schuler G

机构信息

Department of Dermatology, University of Innsbruck, Austria.

出版信息

Res Immunol. 1989 Nov-Dec;140(9):895-8; discussion 918-26. doi: 10.1016/0923-2494(89)90050-3.

DOI:10.1016/0923-2494(89)90050-3
PMID:2697912
Abstract

Langerhans cells are dendritically shaped MHC-class II-bearing leukocytes which reside in the epidermis. During short-term culture, they develop into cells that are virtually indistinguishable from lymphoid dendritic cells with respect to morphology and phenotype, as well as function. It is hypothesized that Langerhans cells in situ represent immature precursors of dendritic cells.

摘要

朗格汉斯细胞是具有树突状形态、表达MHC-II类分子的白细胞，存在于表皮中。在短期培养过程中，它们会发育成在形态、表型以及功能方面与淋巴样树突状细胞几乎无法区分的细胞。据推测，原位的朗格汉斯细胞代表树突状细胞的未成熟前体。

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Structural and functional relationships between epidermal Langerhans cells and dendritic cells.表皮朗格汉斯细胞与树突状细胞之间的结构和功能关系。
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Cellular components of the immune barrier in the spinal meninges and dorsal root ganglia of the normal rat: immunohistochemical (MHC class II) and electron-microscopic observations.
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Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.在培养表皮朗格汉斯细胞时，某些酸性细胞器（内体和朗格汉斯细胞颗粒）的消失伴随着抗原处理能力的丧失。
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