Personne V, Chevalier J, Buffel du Vaure C, Partouche H, Gilberg S, de Pouvourville G
Département de médecine générale, Faculté de médecine, Sorbonne Paris Cité, Université Paris Descartes, Paris, France.
Health Systems, ESSEC Business School, Avenue Bernard Hirsch, BP 50105, 95021 Cergy-Pontoise Cedex, France.
Vaccine. 2016 Apr 27;34(19):2275-80. doi: 10.1016/j.vaccine.2016.03.013. Epub 2016 Mar 12.
Estimating the economic burden of community acquired pneumonia (CAP) managed in ambulatory setting is needed in France since no data are available.
A retrospective study (CAPECO) was conducted based on a prospective French study describing patients with suspected CAP managed in primary care (CAPA). The aim of the CAPECO study was to estimate and explain medical costs of a disease episode in CAP patients only followed in ambulatory care and in hospitalised patients. Primary endpoints were the direct medical costs, impact on productivity and costs of incident CAP over one year. Secondary endpoint was to describe predictive factors of costs, hospital admission and stay length.
In this cohort of 886 patients, resulting in an incidence of CAP of 400 per 100,000 inhabitants per year, the mean direct medical cost of a disease episode of CAP was € 118.8 for strictly ambulatory patients with an equal weight for medical time, drugs, diagnostic procedures and tests. This direct cost was € 102.1 before admission for patients who were finally hospitalised. The mean cost of hospital admissions was € 3522.9. Main predictive factors of hospital admission and stay length were respectively a history of chronic respiratory disease and older age. Factors of direct medical cost were prescribing X-ray examination and having a positive X-ray. The impact of a disease episode on productivity was € 1980 (sd 1400) per ambulatory episode and € 5425 (sd 4760) per episode leading to hospital admission.
Costs per ambulatory episode were modest but increased substantially in hospitalised patients, who were more numerous when chronic respiratory disorders were present and in the elderly. Indirect costs were significant. Deciders should thus consider both direct and indirect costs when assessing preventive interventions in the context of this disease.
由于法国尚无相关数据,因此需要估算在门诊环境中治疗社区获得性肺炎(CAP)的经济负担。
基于一项前瞻性法国研究开展了一项回顾性研究(CAPECO),该前瞻性研究描述了在初级保健机构中接受治疗的疑似CAP患者(CAPA)。CAPECO研究的目的是估算并解释仅接受门诊治疗的CAP患者以及住院患者疾病发作的医疗费用。主要终点是直接医疗费用、对生产力的影响以及一年内CAP发病的费用。次要终点是描述费用、住院和住院时长的预测因素。
在这个包含886名患者的队列中,CAP的发病率为每年每10万居民400例。对于严格意义上的门诊患者,CAP疾病发作的平均直接医疗费用为118.8欧元,医疗时间、药物、诊断程序和检查的权重相同。对于最终住院的患者,入院前的直接费用为102.1欧元。住院的平均费用为3522.9欧元。住院和住院时长的主要预测因素分别是慢性呼吸道疾病史和年龄较大。直接医疗费用的因素是开具X光检查以及X光检查呈阳性。疾病发作对生产力的影响为每门诊发作1980欧元(标准差1400),每导致住院发作5425欧元(标准差4760)。
每门诊发作的费用适中,但住院患者的费用大幅增加,当存在慢性呼吸道疾病以及在老年人中时,住院患者数量更多。间接费用很高。因此,决策者在评估针对该疾病的预防干预措施时应同时考虑直接和间接费用。