RNA对DNA损伤的反应。

The RNA Response to DNA Damage.

作者信息

Giono Luciana E, Nieto Moreno Nicolás, Cambindo Botto Adrián E, Dujardin Gwendal, Muñoz Manuel J, Kornblihtt Alberto R

机构信息

Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-UBA-CONICET), Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina; Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, C1428EHA Buenos Aires, Argentina.

出版信息

J Mol Biol. 2016 Jun 19;428(12):2636-2651. doi: 10.1016/j.jmb.2016.03.004. Epub 2016 Mar 12.

DOI:10.1016/j.jmb.2016.03.004

PMID:26979557

Abstract

Multicellular organisms must ensure genome integrity to prevent accumulation of mutations, cell death, and cancer. The DNA damage response (DDR) is a complex network that senses, signals, and executes multiple programs including DNA repair, cell cycle arrest, senescence, and apoptosis. This entails regulation of a variety of cellular processes: DNA replication and transcription, RNA processing, mRNA translation and turnover, and post-translational modification, degradation, and relocalization of proteins. Accumulated evidence over the past decades has shown that RNAs and RNA metabolism are both regulators and regulated actors of the DDR. This review aims to present a comprehensive overview of the current knowledge on the many interactions between the DNA damage and RNA fields.

摘要

多细胞生物必须确保基因组完整性，以防止突变积累、细胞死亡和癌症发生。DNA损伤反应（DDR）是一个复杂的网络，它能感知、发出信号并执行多个程序，包括DNA修复、细胞周期停滞、衰老和凋亡。这需要对多种细胞过程进行调控：DNA复制和转录、RNA加工、mRNA翻译和周转，以及蛋白质的翻译后修饰、降解和重新定位。过去几十年积累的证据表明，RNA和RNA代谢既是DDR的调节因子，也是受调控的参与者。本综述旨在全面概述目前关于DNA损伤与RNA领域之间众多相互作用的知识。