van Veen Sarit, Aarnoudse-Moens Cornelieke S H, van Kaam Anton H, Oosterlaan Jaap, van Wassenaer-Leemhuis Aleid G
Psychosocial Department, Academic Medical Center, Amsterdam, The Netherlands; Department of Neonatology, Academic Medical Center, Amsterdam, The Netherlands.
Psychosocial Department, Academic Medical Center, Amsterdam, The Netherlands; Department of Neonatology, Academic Medical Center, Amsterdam, The Netherlands.
J Pediatr. 2016 Jun;173:90-5. doi: 10.1016/j.jpeds.2016.02.043. Epub 2016 Mar 12.
To determine the effects of correcting for prematurity on full scale IQ (FSIQ), verbal IQ (VIQ), performance IQ (PIQ), and processing speed quotient (PSQ) scores, and to investigate whether differences between corrected and uncorrected FSIQ are associated with gestational age (GA), FSIQ, and age at assessment.
Single-center consecutive cohort study. Data were analyzed from 275 very preterm children (GA <30 weeks), born between January 2006 and December 2009 and assessed at 5 years corrected age as part of the neonatal long-term follow-up program, at the Emma Children's Hospital in Amsterdam, The Netherlands. Outcome measures were FSIQ, VIQ, PIQ, and PSQ, calculated for uncorrected and corrected age. Paired sample t tests, repeated measures ANOVA, and ANCOVA were performed to explore differences between corrected and uncorrected IQ.
Differences between corrected and uncorrected FSIQ, VIQ, PIQ, and PSQ ranged from 0-15 IQ points. All corrected IQ scores were significantly higher than uncorrected IQ scores (all P values <.001). Differences were larger at lower GAs, for higher IQ scores, and if time of assessment lay near the starting point of a 3-month age band of the Wechsler Preschool and Primary Scale of Intelligence-Third Edition-Dutch Version.
Given the great variation observed in differences between corrected and uncorrected IQ scores, an international standard as to what age correction is appropriate should be pursued.
确定校正早产对全量表智商（FSIQ）、言语智商（VIQ）、操作智商（PIQ）和加工速度商数（PSQ）得分的影响，并调查校正后与未校正的FSIQ之间的差异是否与胎龄（GA）、FSIQ和评估时的年龄相关。
单中心连续队列研究。分析了2006年1月至2009年12月期间出生的275名极早产儿（GA<30周）的数据，这些儿童作为荷兰阿姆斯特丹艾玛儿童医院新生儿长期随访项目的一部分，在矫正年龄5岁时接受了评估。结局指标为未校正和校正年龄时计算的FSIQ、VIQ、PIQ和PSQ。采用配对样本t检验、重复测量方差分析和协方差分析来探讨校正和未校正智商之间的差异。
校正和未校正的FSIQ、VIQ、PIQ和PSQ之间的差异范围为0至15个智商点。所有校正后的智商得分均显著高于未校正的智商得分（所有P值<.001）。在较低的GA、较高的智商得分以及评估时间接近韦氏学前和小学智力量表第三版荷兰语版3个月年龄范围起点时，差异更大。
鉴于校正和未校正智商得分之间的差异存在很大差异，应寻求关于何种年龄校正合适的国际标准。
