Hui Jing, Qu Yuan-Yuan, Tang Na, Liu Yong-Min, Zhong Hua, Wang La-Mei, Feng Qian, Li Zhen, He Fang
Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China.
Department of Emergency and Critical Care Medicine, The First Affiliated Hospital of Medical College of Shihezi University, Shihezi, China.
Wien Klin Wochenschr. 2016 Aug;128(15-16):586-91. doi: 10.1007/s00508-016-0977-x. Epub 2016 Mar 15.
Information regarding association between cytomegalovirus (CMV) infection and essential hypertension (EH) risk is not consistent across studies. Therefore, we conducted a meta-analysis to investigate the association in detail.
We comprehensively searched the published literature from the PubMed and Embase databases for any study analyzing the association between CMV and EH risk. A random-effects model was used to calculate the pooled odds ratio (OR) with 95 % confidence interval (CI).
Three studies involving 9657 patients were included in the meta-analysis, and the results showed a significantly increased risk of EH in patients with CMV infection. Overall, 79.3 % of the hypertension patients were CMV-positive, which was significantly higher than the percentage for controls (OR = 1.39, 95 % CI = 0.95-2.05, P = 0.017). There was significant heterogeneity among the studies included (I(2) = 70.5 %). The funnel plot and Egger's test also indicated no publication bias.
The results showed a significant association between CMV and EH, which indicates that CMV infection is a possible cause of EH.
关于巨细胞病毒（CMV）感染与原发性高血压（EH）风险之间关联的信息在各项研究中并不一致。因此，我们进行了一项荟萃分析以详细研究这种关联。
我们全面检索了来自PubMed和Embase数据库的已发表文献，以查找任何分析CMV与EH风险之间关联的研究。采用随机效应模型计算合并比值比（OR）及95%置信区间（CI）。
三项涉及9657例患者的研究纳入了荟萃分析，结果显示CMV感染患者患EH的风险显著增加。总体而言，79.3%的高血压患者CMV呈阳性，这一比例显著高于对照组（OR = 1.39，95%CI = 0.95 - 2.05，P = 0.017）。纳入的研究之间存在显著异质性（I² = 70.5%）。漏斗图和Egger检验也表明不存在发表偏倚。
结果显示CMV与EH之间存在显著关联，这表明CMV感染可能是EH的一个病因。
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