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阿替普酶静脉溶栓治疗卒中后自发性脾破裂——病例报告及文献复习

Spontaneous Splenic Rupture Following Intravenous Thrombolysis with Alteplase Applied as Stroke Therapy - Case Report and Review of Literature.

作者信息

Aleksic-Shihabi Anka, Jadrijevic Eni, Milekic Nina, Bulicic Ana Repic, Titlic Marina, Suljic Enra

机构信息

Department of Neurology, General Hospital Sibenik, Sibenik, Croatia.

Department of Neurology, University Hospital Center Split, Split, Croatia.

出版信息

Med Arch. 2016 Feb;70(1):69-71. doi: 10.5455/medarh.2016.70.69-71. Epub 2016 Jan 31.

DOI:10.5455/medarh.2016.70.69-71
PMID:26980937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4779351/
Abstract

INTRODUCTION

Stroke is a medical emergency in neurology, and is one of the leading causes of death nowadays. At a recent time, a therapeutic method used in adequate conditions is thrombolysis, a treatment of an emerging clot in the brain vascular system by alteplase. The application of alteplase also has a high risk of life threatening conditions.

CASE REPORT

This is a brief report of a case with thrombolysis complication which manifested as a spleen rupture.

摘要

引言

中风是神经内科的一种医疗急症，是当今主要的死亡原因之一。近期，在适当条件下使用的一种治疗方法是溶栓，即使用阿替普酶治疗脑血管系统中新形成的血栓。阿替普酶的应用也有导致危及生命情况的高风险。

病例报告

这是一份关于溶栓并发症表现为脾破裂病例的简要报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/4779351/cb8652d42d8f/MA-70-69-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/4779351/cb8652d42d8f/MA-70-69-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/983b/4779351/cb8652d42d8f/MA-70-69-g001.jpg

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本文引用的文献

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Spontaneous splenic rupture after thrombolysis for ischemic stroke.缺血性中风溶栓治疗后自发性脾破裂。
Am J Emerg Med. 2015 Mar;33(3):478.e3-4. doi: 10.1016/j.ajem.2014.08.057. Epub 2014 Aug 27.
2
Splenic rupture following thrombolysis treatment for acute myocardial infarction.急性心肌梗死溶栓治疗后脾破裂
J Surg Case Rep. 2012 Jul 1;2012(7):11. doi: 10.1093/jscr/2012.7.11.
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Drug treatment of acute ischemic stroke.急性缺血性脑卒中的药物治疗。
Am J Cardiovasc Drugs. 2013 Feb;13(1):57-69. doi: 10.1007/s40256-013-0007-6.
4
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.1990年和2010年20个年龄组中235种死因的全球和区域死亡率：全球疾病负担研究2010的系统分析
Lancet. 2012 Dec 15;380(9859):2095-128. doi: 10.1016/S0140-6736(12)61728-0.
5
Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials.静脉注射重组组织型纤溶酶原激活剂治疗时间与卒中转归：ECASS、ATLANTIS、NINDS 和 EPITHET 试验的更新汇总分析。
Lancet. 2010 May 15;375(9727):1695-703. doi: 10.1016/S0140-6736(10)60491-6.
6
Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.急性缺血性卒中发病3至4.5小时后使用阿替普酶进行溶栓治疗。
N Engl J Med. 2008 Sep 25;359(13):1317-29. doi: 10.1056/NEJMoa0804656.
7
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.成人缺血性卒中早期管理指南：美国心脏协会/美国卒中协会卒中委员会、临床心脏病学委员会、心血管放射学与介入委员会以及动脉粥样硬化性外周血管疾病与研究跨学科工作组护理质量与转归委员会制定的指南：美国神经病学学会肯定本指南作为神经病学教育工具的价值。
Stroke. 2007 May;38(5):1655-711. doi: 10.1161/STROKEAHA.107.181486. Epub 2007 Apr 12.
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Z Kardiol. 2005 Mar;94(3):200-4. doi: 10.1007/s00392-005-0197-2.
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Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials.早期卒中治疗与预后的关联：ATLANTIS、ECASS及NINDS rt-PA卒中试验的汇总分析
Lancet. 2004 Mar 6;363(9411):768-74. doi: 10.1016/S0140-6736(04)15692-4.