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胰高血糖素瘤与胰高血糖素瘤综合征：一例报告并综述近期治疗进展

Glucagonoma and Glucagonoma Syndrome: A Case Report with Review of Recent Advances in Management.

作者信息

Al-Faouri Ashraf, Ajarma Khaled, Alghazawi Samer, Al-Rawabdeh Sura, Zayadeen Adnan

机构信息

Department of General Surgery, King Hussein Medical Center, Amman 11831, Jordan.

Department of Pathology, King Hussein Medical Center, Amman 11831, Jordan.

出版信息

Case Rep Surg. 2016;2016:1484089. doi: 10.1155/2016/1484089. Epub 2016 Feb 14.

DOI:10.1155/2016/1484089
PMID:26981306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4769757/
Abstract

The rarity of glucagonoma imposes a challenge with most patients being diagnosed after a long period of treatment for their skin rash (months-years). Awareness of physicians and dermatologists of the characteristic necrolytic migratory erythema often leads to early diagnosis. Early diagnosis of glucagonoma even in the presence of resectable liver metastases may allow curative resection. Herein, we present a typical case of glucagonoma treated at our center and review the literature pertinent to its management.

摘要

胰高血糖素瘤极为罕见，这给诊断带来了挑战，大多数患者在出现皮疹后经过长时间（数月至数年）治疗才得以确诊。内科医生和皮肤科医生若能意识到特征性的坏死性游走性红斑，往往可实现早期诊断。即便存在可切除的肝转移灶，早期诊断胰高血糖素瘤仍有可能进行根治性切除。在此，我们呈现我院中心治疗的一例典型胰高血糖素瘤病例，并回顾其治疗相关的文献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/d84259a6add5/CRIS2016-1484089.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/a2492c4ed0ef/CRIS2016-1484089.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/fffd57505d1a/CRIS2016-1484089.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/585be1e9520e/CRIS2016-1484089.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/cf0180ba611d/CRIS2016-1484089.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/d84259a6add5/CRIS2016-1484089.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/a2492c4ed0ef/CRIS2016-1484089.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/fffd57505d1a/CRIS2016-1484089.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/585be1e9520e/CRIS2016-1484089.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/cf0180ba611d/CRIS2016-1484089.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd11/4769757/d84259a6add5/CRIS2016-1484089.005.jpg

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本文引用的文献

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Oncol Lett. 2015 Aug;10(2):1113-1116. doi: 10.3892/ol.2015.3275. Epub 2015 May 27.
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Necrolytic migratory erythema as the first manifestation of pancreatic neuroendocrine tumor.坏死性游走性红斑作为胰腺神经内分泌肿瘤的首发表现
World J Surg Oncol. 2014 Jul 17;12:220. doi: 10.1186/1477-7819-12-220.
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Glucagonoma syndrome: a case report.胰高血糖素瘤综合征：一例报告。
Cancers (Basel). 2025 Mar 21;17(7):1053. doi: 10.3390/cancers17071053.
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Case report: Surgical treatment and literature review of a recurrent case of glucagonoma.病例报告：一例复发性胰高血糖素瘤的外科治疗及文献复习
Front Oncol. 2024 Aug 26;14:1437102. doi: 10.3389/fonc.2024.1437102. eCollection 2024.
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Skin manifestations of neuroendocrine neoplasms: review of the literature.神经内分泌肿瘤的皮肤表现：文献综述
Postepy Dermatol Alergol. 2022 Aug;39(4):656-661. doi: 10.5114/ada.2021.112073. Epub 2022 Jan 18.
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Necrolytic migratory erythema is an important visual cutaneous clue of glucagonoma.坏死松解性游走性红斑是胰高血糖素瘤的重要皮肤视觉线索。
Sci Rep. 2022 May 31;12(1):9053. doi: 10.1038/s41598-022-12882-2.
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How Many Times Can One Go Back to the Drawing Board before the Accurate Diagnosis and Surgical Treatment of Glucagonoma?在对胰高血糖素瘤进行准确诊断和手术治疗之前，一个人可以回到绘图板（重新开始）多少次？
Diagnostics (Basel). 2022 Jan 16;12(1):216. doi: 10.3390/diagnostics12010216.
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Pancreatic neuroendocrine neoplasms: Clinicopathological features and pathological staging.胰腺神经内分泌肿瘤：临床病理特征和病理分期。
Histol Histopathol. 2021 Apr;36(4):367-382. doi: 10.14670/HH-18-288. Epub 2020 Dec 11.
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Acute onset of necrolytic migratory erythema mimicking an erythema multiforme.急性起病的坏死性游走性红斑，类似多形红斑。
Postepy Dermatol Alergol. 2020 Oct;37(5):817-819. doi: 10.5114/ada.2020.100495. Epub 2020 Nov 7.
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Glucagonoma: From skin lesions to the neuroendocrine component (Review).胰高血糖素瘤：从皮肤病变到神经内分泌成分（综述）
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Multimodality treatment of unresectable hepatic metastases from pancreatic glucagonoma.胰高血糖素瘤不可切除性肝转移的多模态治疗
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Radioembolization with selective internal radiation microspheres for neuroendocrine liver metastases.使用选择性内部放射微球进行放射性栓塞治疗神经内分泌性肝转移瘤。
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Metastatic glucagonoma: treatment with liver transplantation.转移性胰高血糖素瘤：肝移植治疗
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The glucagonoma syndrome and necrolytic migratory erythema: a clinical review.胰高血糖素瘤综合征与坏死性游走性红斑：临床综述
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The glucagonoma syndrome. Clinical and pathologic features in 21 patients.胰高血糖素瘤综合征。21例患者的临床和病理特征。
Medicine (Baltimore). 1996 Mar;75(2):53-63. doi: 10.1097/00005792-199603000-00002.
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"Cutaneous manifestations of internal malignant tumors" by Becker, Kahn and Rothman, June 1942. Commentary: Migratory necrolytic erythema.贝克尔、卡恩和罗斯曼所著的《体内恶性肿瘤的皮肤表现》，1942年6月。评论：游走性坏死性红斑。
Arch Dermatol. 1982 Oct;118(10):784-98. doi: 10.1001/archderm.118.10.784.