Ohara Nobumasa, Kaneko Masanori, Nishibori Takeaki, Sato Kazuhiro, Furukawa Tatsuo, Koike Tadashi, Sone Hirohito, Kaneko Kenzo, Kamoi Kyuzi
Department of Endocrinology and Metabolism, Nagaoka Red Cross Hospital, Japan.
Intern Med. 2016;55(6):643-6. doi: 10.2169/internalmedicine.55.5292. Epub 2016 Mar 15.
A 65-year-old Japanese man presented to our hospital in June 2013 with a 6-day history of fever and fatigue, a 24-h history of thirst, and polyuria. His temperature was 37.8°C and he was alert. However, laboratory tests revealed severe hyperglycemia, undetectable C-peptide levels, and diabetic ketoacidosis. Serum antibody testing confirmed a Coxsackie virus A2 infection. A variety of viral infections are reported to be involved in the development of fulminant type 1 diabetes mellitus (FT1D). Our patient is the first reported case of FT1D associated with Coxsackie virus A2 infection and supports the etiological role of common viral infections in FT1D.
一名65岁的日本男性于2013年6月因发热、乏力6天，口渴、多尿24小时就诊于我院。体温37.8°C，意识清醒。然而，实验室检查显示严重高血糖、C肽水平检测不到及糖尿病酮症酸中毒。血清抗体检测证实为柯萨奇病毒A2感染。据报道，多种病毒感染与暴发性1型糖尿病（FT1D）的发生有关。我们的患者是首例报道的与柯萨奇病毒A2感染相关的FT1D病例，支持常见病毒感染在FT1D中的病因学作用。
