Numa Soichiro, Kasai Takashi, Kondo Takayuki, Kushimura Yukie, Kimura Ayaka, Takahashi Hisashi, Morita Kanako, Tanaka Akihiro, Noto Yu-Ichi, Ohara Tomoyuki, Nakagawa Masanori, Mizuno Toshiki
Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan.
Intern Med. 2016;55(6):699-702. doi: 10.2169/internalmedicine.55.5727. Epub 2016 Mar 15.
Acute disseminated encephalomyelitis (ADEM) followed by optic neuritis (ON) has been reported as a distinct phenotype associated with anti-myelin oligodendrocyte protein (MOG) antibody. We herein report the case of a 37-year-old woman who was diagnosed with ADEM at 4 years old of age and who subsequently developed ON followed by recurrent ADEM 33 years after the initial onset. A serum analysis showed anti-MOG antibody positivity. This phenotype has only previously been reported in pediatric cases. Neurologists thus need to be aware that the phenotype may occur in adult patients, in whom it may be assumed to be atypical multiple sclerosis.
急性播散性脑脊髓炎（ADEM）后继发视神经炎（ON）已被报道为一种与抗髓鞘少突胶质细胞糖蛋白（MOG）抗体相关的独特表型。我们在此报告一例37岁女性病例，该患者4岁时被诊断为ADEM，最初发病33年后继发ON，随后ADEM复发。血清分析显示抗MOG抗体呈阳性。这种表型此前仅在儿科病例中被报道过。因此，神经科医生需要意识到这种表型可能发生在成年患者中，在这些患者中可能被认为是非典型多发性硬化症。
