Liu Kang, Min Xu-Li, Peng Juan, Yang Ke, Yang Lin, Zhang Xiao-Ming
Department of Pain Management, Xianyang Hospital, Yan'an University, Xianyang, Shanxi 712000, China; Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
J Clin Med Res. 2016 Apr;8(4):297-302. doi: 10.14740/jocmr2496w. Epub 2016 Feb 27.
As a common malignant tumor, hepatocellular carcinoma (HCC) has a high prevalence and is a serious threat to human health. The surgical resection rate of HCC is low, and the prognosis is poor. Although transarterial chemoembolization (TACE) is the main treatment for HCC patients who are not candidates for surgical resection, it is not considered a curative procedure. For HCC, poor TACE efficacy or TACE failure may be related to tumor angiogenesis of the residual disease. Among the many regulatory factors in tumor angiogenesis, hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) play vital roles in this process. In this paper, we conducted a review of the dynamic change and relevance of HIF-1α and VEGF levels after TACE of HCC patients.
作为一种常见的恶性肿瘤，肝细胞癌（HCC）发病率高，对人类健康构成严重威胁。HCC的手术切除率低，预后较差。尽管经动脉化疗栓塞术（TACE）是无法进行手术切除的HCC患者的主要治疗方法，但它并不被视为一种根治性手术。对于HCC而言，TACE疗效不佳或TACE失败可能与残留病灶的肿瘤血管生成有关。在肿瘤血管生成的众多调节因子中，缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）在此过程中起着至关重要的作用。本文对HCC患者TACE术后HIF-1α和VEGF水平的动态变化及相关性进行了综述。
