循环胎盘生长因子作为卵巢子宫内膜异位症诊断筛查标志物的性能：一项初步研究。
Performance of Circulating Placental Growth Factor as A Screening Marker for Diagnosis of Ovarian Endometriosis: A Pilot Study.
作者信息
Zucchini Cinzia, De Sanctis Paola, Facchini Chiara, Di Donato Nadine, Montanari Giulia, Bertoldo Valentina, Farina Antonio, Curti Alessandra, Seracchioli Renato
机构信息
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Pelvic Endoscopy and Minimally Invasive Gynaecologic Surgery, St. Orsola Malpighi University Hospital, Bologna, Italy.
出版信息
Int J Fertil Steril. 2016 Jan-Mar;9(4):483-9. doi: 10.22074/ijfs.2015.4606. Epub 2015 Dec 23.
BACKGROUND
The aim of this study is to compare the circulating placental growth factor (PlGF) concentration in women with and without endometrioma to verify the performance of this marker to diagnose the disease.
MATERIALS AND METHODS
In this case-control study, thirteen women with histological diagnosis of ovarian endometriosis were compared with women without endometriosis disease. PlGF plasma levels of endometriotic patients and controls were investigated using a fluorescence immunoassay technique.
RESULTS
PlGF showed a direct correlation with body mass index (BMI) only in the control group (P=0.013). After adjustment for BMI values, PlGF median value in endometriosis group (14.7 pg/mL) resulted higher than in control group (13.8 pg/ mL, P=0.004).
CONCLUSION
PlGF is a promising peripheral blood marker that can discriminate between patients with and without ovarian endometriosis.
背景
本研究旨在比较患有和未患有子宫内膜异位囊肿的女性循环胎盘生长因子（PlGF）浓度，以验证该标志物对疾病的诊断性能。
材料与方法
在这项病例对照研究中，将13例经组织学诊断为卵巢子宫内膜异位症的女性与未患子宫内膜异位症的女性进行比较。采用荧光免疫分析技术检测子宫内膜异位症患者和对照组的血浆PlGF水平。
结果
仅在对照组中，PlGF与体重指数（BMI）呈直接相关性（P = 0.013）。在对BMI值进行校正后，子宫内膜异位症组的PlGF中位数（14.7 pg/mL）高于对照组（13.8 pg/mL，P = 0.004）。
结论
PlGF是一种有前景的外周血标志物，可区分患有和未患有卵巢子宫内膜异位症的患者。
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